代谢综合征各组分与良性前列腺增生症的相关性研究

发布时间：2018-03-21 17:06

本文选题：前列腺增生　切入点：代谢综合征　出处：《中国全科医学》2017年02期 　论文类型：期刊论文

【摘要】：背景流行病学研究显示,代谢综合征(MS)与良性前列腺增生症(BPH)具有密切联系,MS可能是加剧BPH的危险因素,而且MS某些相关指标可能是BPH的预测因素。目的探讨MS各组分对BPH的影响,分析BPH疾病进展的可能危险因素,从而为临床防治BPH提供依据。方法选取2013年1月—2014年10月首都医科大学附属北京安贞医院泌尿外科收治的BPH合并MS患者214例为研究对象。记录患者年龄、吸烟史、饮酒史、体质指数(BMI),检测低密度脂蛋白胆固醇(LDL-C)、血尿酸、尿微量清蛋白水平。B超检测前列腺体积、膀胱残余尿量,采用尿流动力学分析仪检测最大尿流率,以国际前列腺症状评分(IPSS)评价患者下尿路症状严重程度。结果多元线性回归分析显示,年龄是BPH合并MS患者前列腺体积、膀胱残余尿量、最大尿流率、IPSS的影响因素(b=0.223、0.778、-0.151、0.116,P0.01),LDL-C是BPH合并MS患者最大尿流率的影响因素(b=-0.441,P0.01),尿微量清蛋白是BPH合并MS患者IPSS的影响因素(b=0.023,P0.01)。结论 MS与BPH密切相关,LDL-C和尿微量清蛋白改变可能是MS、BPH的共同环节,可加剧BPH患者疾病发展。
[Abstract]:Background Epidemiological studies show that metabolic syndrome (MS) is closely associated with benign prostatic hyperplasia (BPH) and MS may be a risk factor for exacerbating BPH. Some related indexes of MS may be the predictors of BPH. Objective to investigate the effect of MS components on BPH and analyze the possible risk factors for the progression of BPH. Methods from January 2013 to October 2014, 214 patients with BPH combined with MS in Urology Department, Beijing Anzhen Hospital affiliated to Capital Medical University were selected as study subjects. The patients' age, smoking history and drinking history were recorded. Body mass index (BMI), low density lipoprotein cholesterol (LDL-C), serum uric acid (uric acid), urinary microalbuminuria (UAP), prostate volume and bladder residual urine volume were measured by B-ultrasound, and the maximum flow rate was measured by urodynamics analyzer. Results multiple linear regression analysis showed that age was the volume of prostate and residual urine volume of bladder in BPH patients with MS. The influencing factors of maximum urinary flow rate and IPSS in patients with BPH and MS were 0.223U 0.778- 0.151U 0.116P0.01U LDL-C and P0.01C, respectively. Conclusion MS is closely related to BPH and urinary microalbuminuria is the influence factor of IPSS in patients with BPH and MS. Conclusion there is a close relationship between BPH and LDL-C and urinary microalbumins in patients with BPH and MS, and the changes of serum albumin in urine are closely related to the changes of LDL-C and urinary microalbumins in patients with MS. May be a common link in MSN BPH, Can aggravate the disease development of BPH patients.
【作者单位】：首都医科大学附属北京安贞医院泌尿外科;
【分类号】：R697.32;;R589

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