血清高敏C反应蛋白和白蛋白在SLE患者预后评估中的作用

发布时间：2018-03-22 04:32

  本文选题：高敏C反应蛋白　切入点：白蛋白　出处：《中国实验血液学杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的:研究高敏C反应蛋白(hs CRP)及白蛋白(Alb)比值(hs CRP/Alb)在系统性红斑狼疮(SLE)患者预后评估中的作用。方法:选取2011年1月-2016年1月期间本院收治的126例SLE患者,收集患者临床资料:包括治疗前后的SLE疾病活动指数评分(SLEDAI)、hs CRP和Alb水平及治疗过程中并发症的发生情况,分析hs CRP和Alb比值与治疗后SLEDAI及并发症的相关性。所有患者出院后均接受随访,分析患者预后的相关因素。结果:治疗后10-14分患者的hs CRP/Alb比值高于5-9分者及0-4分者,差异具有统计学意义(P0.05)。hs CRP/Alb比值与患者的感染(r=0.574),肾脏损害(r=0.499)及心脏损害(r=0.516)的发生呈正相关(P0.05),与血液系统损害、中枢神经系统损害及肺损害的发生无显著相关性(P0.05)。治疗后SLEDAI≥10、hs CRP/Alb≥0.05 mg/g及住院期间并发症是患者预后的相关因素(P0.05)。结论:hs CRP/Alb与SLE患者的预后具有一定的相关性。
[Abstract]:Objective: to study the prognostic value of Gao Min C-reactive protein hs CRP and Alb / Alb ratio in patients with systemic lupus erythematosus (SLE). Methods: 126 patients with SLE were selected from January 2011 to January 2016. To collect the clinical data of the patients: including the SLE disease activity index scores before and after treatment, the levels of CRP and Alb of SLEDAIHs and the occurrence of complications during the treatment. To analyze the correlation between hs CRP and Alb ratio, SLEDAI and complications after treatment. All the patients were followed up after discharge, and the prognostic factors were analyzed. Results: the hs CRP/Alb ratio of patients with 10-14 points after treatment was higher than that of patients with 5-9 points and 0-4 points. There was a positive correlation between the ratio of P0.05hs CRP/Alb and the incidence of blood system damage, and the incidence of renal damage, renal injury, and cardiac damage were positively correlated with the incidence of blood system damage, and there was a positive correlation between the ratio of P0.05hs CRP/Alb and the incidence of blood system damage. There was no significant correlation between central nervous system damage and lung injury (P 0.05). SLEDAI 鈮，

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