米诺环素治疗中重度慢性牙周炎合并2型糖尿病的临床观察

发布时间：2018-03-24 07:19

本文选题：米诺环素　切入点：慢性牙周炎　出处：《中国药房》2017年23期

【摘要】：目的:探讨米诺环素对中重度慢性牙周炎合并2型糖尿病患者的临床指标、炎症因子和血糖的影响。方法:选取我院2013年2月-2015年8月收治的中重度慢性牙周炎合并2型糖尿病患者125例,按照随机数字表法分为对照组(63例)和观察组(62例)。两组患者均给予洁治术和根面平整术等牙周基础治疗;对照组患者术后给予碘甘油注满牙周袋,2~4次/d;观察组患者术后给予盐酸米诺环素软膏注满牙周袋,每周1次。两组患者均治疗4周。观察两组患者治疗前和治疗后3个月的临床指标[探诊深度、临床附着水平(CAL)和探诊出血率]、血清炎症因子(C反应蛋白和肿瘤坏死因子α)、血糖(空腹血糖和糖化血红蛋白)水平,并记录不良反应发生情况。结果:治疗前,两组患者临床指标、血清炎症因子和血糖水平比较,差异均无统计学意义(P0.05)。治疗后3个月,两组患者探诊深度、探诊出血率和血清炎症因子水平均明显降低,且观察组明显低于对照组,差异均有统计学意义(P0.05);两组患者CAL均较治疗前增加,但治疗前后比较、组间比较差异均无统计学意义(P0.05);两组患者空腹血糖均明显降低,差异有统计学意义(P0.05),但组间比较差异无统计学意义(P0.05);对照组患者糖化血红蛋白水平较治疗前降低,但差异无统计学意义(P0.05);观察组患者糖化血红蛋白水平明显降低,且观察组明显低于对照组,差异有统计学意义(P0.05)。观察组患者不良反应发生率(3.23%)与对照组(0)比较,差异无统计学意义(P0.05)。结论:米诺环素治疗中重度慢性牙周炎合并2型糖尿病可有效改善患者牙周炎的临床指标,降低血清炎症因子和血糖水平,且安全性较高。
[Abstract]:Objective: to study the clinical indexes of minocycline in patients with moderate and severe chronic periodontitis complicated with type 2 diabetes mellitus. Methods: 125 patients with moderate and severe chronic periodontitis complicated with type 2 diabetes mellitus from February 2013 to August 2015 were selected. The patients in the two groups were divided into two groups: control group (n = 63) and observation group (n = 62). The patients in the control group were given iodine glycerol to fill the periodontal bag for 4 times per day, and the patients in the observation group were given minocycline hydrochloride ointment to fill the periodontal bag after operation. Once a week, both groups were treated for 4 weeks. The clinical indexes before and 3 months after treatment in both groups were observed. Clinical adhesion level (CAL) and diagnostic bleeding rate], serum inflammatory factor C reactive protein (CRP) and tumor necrosis factor alpha (TNF- 伪), blood glucose (fasting blood glucose and glycosylated hemoglobin), and the occurrence of adverse reactions were recorded. There was no significant difference in clinical indexes, serum inflammatory factors and blood glucose levels between the two groups. After 3 months of treatment, the depth, bleeding rate and serum inflammatory factor level of the two groups were significantly lower than those of the control group. The CAL of the two groups was significantly higher than that of the control group, but there was no significant difference between the two groups before and after treatment, and the fasting blood glucose in the two groups was significantly lower than that in the control group, and there was no significant difference between the two groups before and after treatment, and there was no significant difference between the two groups before and after treatment. The difference was statistically significant (P 0.05), but there was no significant difference between the two groups (P 0.05), the level of glycosylated hemoglobin in the control group was lower than that before treatment, but the difference was not statistically significant (P 0.05), the level of glycosylated hemoglobin in the observation group was significantly lower than that in the control group. The incidence of adverse reactions in the observation group was 3.23 (P < 0.05), which was significantly lower than that in the control group (P 0.05). Conclusion: minocycline in the treatment of moderate and severe chronic periodontitis combined with type 2 diabetes mellitus can effectively improve the clinical indicators of periodontitis, reduce the level of serum inflammatory factors and blood sugar, and the safety is higher.
【作者单位】：广安市人民医院检验科;广安市人民医院口腔科;
【分类号】：R587.1;R781.42

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