低强度脉冲超声治疗骨质疏松的可行性分析

发布时间：2018-03-24 18:16

本文选题：骨质疏松　切入点：低强度脉冲超声　出处：《科学通报》2016年26期

【摘要】：骨质疏松症是一种全身性骨骼系统疾病,以骨量减少、骨微结构退化为主要特征,常伴有骨痛、驼背、骨折等症状,严重影响患者生活质量.目前骨质疏松治疗以药物治疗为主,但副作用较大.物理疗法低强度脉冲超声(LIPUS)则可以避免药物不良反应,且具有无创伤、无电离辐射等优点.研究表明,LIPUS刺激在骨折愈合中具有积极作用,而骨折和骨质疏松治疗时某些生物机制相似,因此LIPUS可能是治疗骨质疏松的重要潜在手段.本文通过查阅以"LIPUS"、"骨折"、"骨质疏松"为主题的大量相关资料并进行归纳总结,从骨组织结构与功能、LIPUS治疗骨病的生物学机制以及LIPUS治疗骨质疏松的实验研究入手,分析论证LIPUS治疗骨质疏松的有效依据,对LIPUS治疗骨质疏松研究现状进行综述,以期为治疗骨质疏松提供新的思路和理论依据.
[Abstract]:Osteoporosis is a systemic skeletal system disease characterized by reduced bone mass and degeneration of bone microstructure, often accompanied by bone pain, humpback, fracture, etc. At present, the main treatment for osteoporosis is drug therapy, but the side effects are larger. Physical therapy with low intensity pulsed ultrasound (LIPUS) can avoid adverse drug reactions and has no trauma. Studies have shown that LIPUS stimuli play a positive role in fracture healing, while some biological mechanisms are similar in the treatment of fractures and osteoporosis. Therefore, LIPUS may be an important potential method for the treatment of osteoporosis. In this paper, a large number of related data on the topics of "LIPUS", "fracture" and "osteoporosis" were reviewed and summarized. Based on the biological mechanism of bone tissue structure and function and the experimental study of LIPUS in the treatment of osteoporosis, this paper analyzes and proves the effective basis of LIPUS in the treatment of osteoporosis, and summarizes the present research situation of LIPUS in the treatment of osteoporosis. In order to provide new ideas and theoretical basis for the treatment of osteoporosis.
【作者单位】：复旦大学电子工程系;上海市医学图像处理与计算机辅助手术重点实验室;Department
【基金】：国家杰出青年科学基金(11525416) 国家自然科学基金(11174060,11327405) 上海市科技支撑计划(13441901900)资助
【分类号】：R580;TB559

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