HIV潜伏感染激活剂的研究进展

发布时间：2018-03-28 06:12

本文选题：艾滋病　切入点：HIV病毒潜伏储存库　出处：《病毒学报》2017年02期

【摘要】：艾滋病是由人类免疫缺陷病毒(Human immunodeficiency virus,HIV)引起的人类最严重的单一病因疾病,以全身免疫系统严重损害为特征。高效抗逆转录病毒疗法(Highly active anti-retroviral therapy,HAART)的应用已经成功地将艾滋病从一种致死性疾病转变为慢性可控性疾病。但长期接受HAART治疗的艾滋病患者一旦停药,患者体内潜伏的HIV会迅速反弹。艾滋病无法彻底治愈的原因是患者体内HIV病毒潜伏储存库的存在。"Shock and kill"策略是使用HIV潜伏感染激活剂(Latency-reversing agents,LRAs)诱导潜伏HIV前病毒复制及表达,然后联合HAART将病毒一网打尽,同时由于细胞病变效应和/或HIV特征性免疫反应使潜伏细胞的半衰期大大缩短,最终达到功能性治愈的目的。因此,高效、安全且特异性促进潜伏库衰减的LRAs成为现今艾滋病治愈研究的热点。本文聚焦国内外前沿研究,对具有临床发展前景的HIV潜伏感染激活剂做一综述,为未来LRAs药物的研发指明方向。
[Abstract]:AIDS is the most serious single cause of disease in humans caused by human immunodeficiency virus (HIV). The use of highly effective active anti-retroviral therapy has successfully transformed AIDS from a fatal disease to a chronic controllable disease. But long-term treatment with HAART. Once the AIDS patient stops taking the drug, Latent HIV in patients can bounce back quickly. The reason that AIDS cannot be cured completely is the existence of latent repository of HIV virus in patients. The strategy of "Shock and kill" is to use HIV latent infection activator, Latency-reversing agents, to induce the replication and expression of latent HIV previrus. Then combined with HAART, the virus was wiped out, and the half-life of the latent cells was greatly shortened because of cytopathic effects and / or HIV characteristic immune responses, which ultimately achieved the purpose of functional healing. LRAs, which is safe and specific to promote the decay of latent library, has become a hot spot in the research of AIDS cure. This article focuses on the frontier research at home and abroad, and reviews the potential of HIV latent infection activator in clinical development. For the future research and development of LRAs drugs to point out the direction.
【作者单位】：南方医科大学药学院广东省新药筛选重点实验室广州市新发病毒防治药物研究重点实验室;
【基金】：国家自然科学基金面上项目(项目号:81673481),题目:抗CD45RO抗体-JQ1偶联物激活HIV潜伏库的作用及机制研究 2016年“攀登计划”广东大学生科技创新培育专项,题目:RVX-208作为HIV潜伏库激活剂的研究
【分类号】：R512.91

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