血清Irisin水平与代谢综合征关系的临床研究

发布时间：2018-03-28 10:28

本文选题：Irisin　切入点：代谢综合征　出处：《四川大学学报(医学版)》2017年01期

【摘要】：目的探讨血清Irisin水平与代谢综合征(MetS)的关系。方法收集四川大学华西医院内分泌科门诊未用药的确诊为代谢综合征的患者33例,以及与之年龄、性别匹配的健康志愿者33例临床资料。检测其各代谢指标及空腹血清Irisin水平并比较分析。结果代谢综合征组血清Irisin质量浓度〔(8.53±2.59)ng/mL〕与健康对照组Irisin浓度〔(8.71±2.84)ng/mL〕差异无统计学意义(P=0.809);经Pearson相关分析,代谢综合征组的血清Irisin质量浓度与臀围(r=-0.531,P0.001)、血尿酸(r=-0.414,P=0.023)呈负相关,而与其他MetS参数(腰围、腰臀比、糖化血红蛋白、血脂等)相关性均无统计学意义。结论未用药的代谢综合征患者血清Irisin水平与健康人无明显差异。血清Irisin作为代谢综合征生物标志物的意义较小。
[Abstract]:Objective to investigate the relationship between serum Irisin level and metabolic syndrome (MetS). Methods 33 patients with metabolic syndrome who were diagnosed as metabolic syndrome in Department of Endocrinology, West China Hospital, Sichuan University, and their ages were collected. The clinical data of 33 healthy volunteers matched by sex. The metabolic indexes and fasting serum Irisin levels were measured and compared. Results the serum Irisin concentration in metabolic syndrome group was 8.53 卤2.59 ng / mL and 8.71 卤2.84 ng / mL respectively in metabolic syndrome group, and there was no statistical difference in Irisin concentration between metabolic syndrome group and healthy control group (8.71 卤2.84 ng / mL). By Pearson correlation analysis, In the metabolic syndrome group, the serum Irisin concentration was negatively correlated with the hip circumference r-0.531g P0.001, and the serum uric acid r-0.414PnP 0.023, but was negatively correlated with other MetS parameters (waist circumference, waist-hip ratio, glycosylated hemoglobin). Conclusion there is no significant difference in serum Irisin level between untreated metabolic syndrome patients and healthy people. Serum Irisin is a biomarker of metabolic syndrome.
【作者单位】：四川大学华西医院全科医学科;四川大学华西医院内分泌代谢科;四川大学华西医院实验医学科;四川大学华西医院中国循证医学中心;
【基金】：国家自然科学基金(No.81400811和No.21534008)资助
【分类号】：R589

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