胰岛素降解酶活性与2型糖尿病患者认知功能障碍的相关性研究

发布时间：2018-03-28 22:23

本文选题：胰岛素降解酶　切入点：型糖尿病　出处：《中国现代医学杂志》2016年01期

【摘要】：目的探讨胰岛素降解酶(IDE)活性与2型糖尿病(T2DM)患者认知功能障碍的相关性。方法筛选2015年5月-2015年7月在唐山市工人医院内分泌二科住院的T2DM患者80例为病例组,同期体检健康者80例为对照组,收集所有研究对象的一般资料,包括性别、年龄、受教育年限、收缩压(SBP)、舒张压(DBP)、体重指数(BMI)、病程等,以及生化指标,包括超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)、空腹血糖(FPG)、空腹胰岛素(FIN)、糖化血红蛋白(Hb A1c)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等。计算稳态胰岛素评价指数(HOMA-IR)(空腹胰岛素×空腹血糖/22.5)并进行可重复的成套神经心理状态测量量表(RBANS)评分。应用IDE活性试剂盒(IDE Immunoca Pture Act)检测血清IDE活性水平,比较对照组与病例组IDE活性及认知功能是否存在差异,并分析IDE与认知功能的相关性。将病例组按照IDE活性中位数水平分为高IDE活性水平组和低IDE活性水平组,比较两组之间认知功能是否存在差异。结果 1与对照组比较,病例组患者病程长,BMI、FPG、Hb A1c、TC、TG、LDL-C、hs-CRP、Hcy、HOMA-IR水平较高,IDE活性水平降低(P0.05),而年龄、性别、受教育年限、血压、HDL比较,差异无统计学意义(P0.05);2与对照组比较,病例组RBANS量表即时记忆、言语功能、注意力、延迟记忆、总分降低(P0.05);3在病例患者中,与高IDE活性水平组相比,低IDE活性水平组即时记忆、视觉广度、言语功能、注意力、延迟记忆评分以及总分降低(P0.01);4在病例患者中,IDE活性与IR呈负相关(P0.01);5在病例患者中,IDE与即刻记忆、视觉广度、言语功能、注意力、延迟功能、总分呈正相关(P0.01)。结论病例患者血清IDE活性水平下降是认知功能降低的危险因素之一。
[Abstract]:Objective to investigate the relationship between the activity of insulin degrading enzyme (IDE) and cognitive dysfunction in type 2 diabetes mellitus (T2DM) patients. Methods 80 patients with T2DM were selected from May 2015 to July 2015 in Department of Endocrine, Tangshan Workers' Hospital as the case group. During the same period, 80 healthy subjects were selected as control group. The general data of all subjects were collected, including sex, age, years of education, SBP, DBP, BMI, course of disease, and biochemical indexes. The results were as follows: hypersensitive C-reactive protein (hs-CRPN), homocysteine (Hcyn), fasting blood glucose (FPG), fasting insulin (FINA), glycosylated hemoglobin (HbA1cN), total cholesterol (TC), triacylglycerol (TGG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and so on. The homeostasis insulin evaluation index (HOMA-IRT) and the repeatable set of neuropsychological state measurement scale (RBANS) were evaluated. Serum IDE activity was measured by IDE activity kit and IDE Immunoca Pture activity. To compare the difference of IDE activity and cognitive function between control group and case group, and to analyze the correlation between IDE and cognitive function. According to the median level of IDE activity, the case group was divided into high IDE activity group and low IDE activity group. Results 1Compared with the control group, the course of disease of the patients was longer than that of the control group. Results: compared with the control group, the patients in the case group had a longer course of disease than the control group. The patients in the case group had a longer course of disease than the control group, and the higher the level of LDL-Cnhs-CRPU HcyHOMA-IR, the lower the activity level of Ide, while the lower the activity of IDE, the lower the level of HDL, the higher the age, the gender, the years of education, the higher the blood pressure and HDL. There was no significant difference between the two groups in terms of instant memory, speech function, attention, delayed memory, total score of P0.05 and P0.05, compared with the control group. In the case group, compared with the group with high IDE activity level, the patients with low IDE activity level had immediate memory. The scores of visual span, speech function, attention, delayed memory, and total score were negatively correlated with IR in patients with Ide, and between IDE and immediate memory, visual span, speech function, attention, delayed function in patients. Conclusion the decrease of serum IDE activity is one of the risk factors of cognitive impairment.
【作者单位】：华北理工大学研究生院;河北省唐山市工人医院内分泌二科;
【基金】：河北省自然科学基金(No:H2015105083)
【分类号】：R587.2

【相似文献】