哮喘患者外周血血小板-淋巴细胞比值和中性粒细胞-淋巴细胞比值的临床意义

发布时间：2018-03-30 02:11

本文选题：支气管哮喘　切入点：中性粒细胞-淋巴细胞比值　出处：《南方医科大学学报》2017年01期

【摘要】：目的探讨外周血中性粒细胞-淋巴细胞比值(neutrophil-lymphocyte ratio,NLR)和血小板-淋巴细胞比值(plateletlymphocyte ratio,PLR)在支气管哮喘急性发作期患者中的变化及临床意义。方法选取2013年1月~2016年5月期间确诊的支气管哮喘急性发作期患者262例为病例组及130例健康体检者为正常对照组。根据其急性发作期病情严重程度,将哮喘患者分为危重组87例、非危重组175例。记录病例组和健康对照组性别、年龄等临床资料和血常规结果,并计算NLR和PLR。比较3组间中性粒细胞绝对值、淋巴细胞绝对值、血小板计数、NLR、PLR的差异,以ROC曲线评价各指标对哮喘的诊断价值。结果各组间中性粒细胞绝对值、淋巴细胞绝对值、NLR、PLR差异具有统计学意义(P0.0001),各组血小板计数差异无统计学意义(P=0.971)。哮喘危重组淋巴细胞绝对值低于哮喘非危重组、健康对照组(P0.0001),而中性粒细胞绝对值、NLR、PLR显著高于哮喘危重组、健康对照组(P0.0001)。哮喘非危重组中性粒细胞绝对值、淋巴细胞绝对值、NLR、PLR与健康对照组相比差异无统计学意义(P0.05)。中性粒细胞绝对值、淋巴细胞绝对值、NLR、PLR对支气管哮喘急性发作期危重患者诊断的曲线下面积分别为0.802、0.784、0.873、0.795(均P0.01)。NLR诊断支气管哮喘急性发作期危重患者的最佳临界值为2.58,敏感度为82.8%,特异度为81.1%。结论支气管哮喘患者外周血NLR、PLR均升高,对支气管哮喘的诊断和病情监测有一定临床指导意义。
[Abstract]:Objective to investigate the changes and clinical significance of neutrophil-lymphocyte ratio (neutrophil-lymphocyte) and platelet-lymphocyte ratio (PLR) in patients with acute asthma. 262 patients with acute episode of bronchial asthma were diagnosed as case group and 130 healthy persons as normal control group. According to the severity of acute attack of bronchial asthma, The patients with asthma were divided into two groups: 87 patients with critical recombination and 175 patients with non-risk recombinant. The clinical data and blood routine results such as sex, age and NLR were recorded, and the absolute values of neutrophils and lymphocytes were compared among the three groups. The ROC curve was used to evaluate the diagnostic value of each index in asthma. Results the absolute value of neutrophils in each group was determined. The absolute value of lymphocytes was significantly different from that of NLRN PLR (P 0.0001), but the platelet count of each group had no significant difference. The absolute value of recombinant lymphocytes in asthma was lower than that in non-risk asthmatic recombination, and there was no significant difference in platelet count in each group. The absolute value of neutrophils and neutrophils in healthy control group was significantly higher than that in asthma risk group, and the absolute value of non-risk recombinant neutrophil in healthy control group was significantly higher than that in asthmatic risk group. There was no significant difference in lymphocyte absolute value between NLRN PLR and healthy control group (P 0.05). The area under the curve for the diagnosis of critical patients with acute attack of bronchial asthma was 0.802 / 0.784 / 0.873 / 0.795 (respectively) (the best critical value of P0.01).NLR for the diagnosis of critical patients with acute attack of bronchial asthma was 2.58, the sensitivity was 82.8 and the specificity was 82.8%). Conclusion Peripheral blood NLR PLR increased in patients with bronchial asthma. It has certain clinical guiding significance for the diagnosis and condition monitoring of bronchial asthma.
【作者单位】：郑州大学第一附属医院检验科//河南省检验医学重点实验室//郑州大学医学检验系;
【基金】：国家自然科学基金(81501715) 河南省科技攻关项目(162102310142,152102410067)~~
【分类号】：R562.25

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