甲巯咪唑联合穴位敷贴治疗贴对甲状腺功能亢进症患者激素水平及骨代谢指标的影响

发布时间：2018-03-30 10:23

本文选题：甲状腺功能亢进症　切入点：甲巯咪唑　出处：《中国药房》2017年21期

【摘要】：目的:探讨甲巯咪唑联合穴位敷贴治疗贴对甲状腺功能亢进症患者激素水平及骨代谢指标的影响。方法:150例甲状腺功能亢进症患者随机分为A组(50例)、B组(50例)和C组(50例)。在常规治疗的基础上,A组患者给予甲巯咪唑片起始剂量20~40 mg,口服,每日1~2次,连用2~6周后若病情改善,则减量至2.5~10 mg并维持,若无改善则维持20~40 mg;B组患者给予穴位敷贴治疗贴1贴,每日早餐后1 h贴于足三里、三阴交、神门、太冲、内关等穴位处。C组患者给予甲巯咪唑片(用法用量同A组)+穴位敷贴治疗贴(用法用量同B组)。3组疗程均为2个月。观察3组患者治疗前后促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离四碘甲状腺原氨酸(FT4)、三碘甲状腺原氨酸(T3)、四碘甲状腺原氨酸(T4)、睾酮(T)、雌二醇(E2)、黄体生成素(LH)、卵泡刺激素(FSH)、血清降钙素(CT)、骨钙素(BGP)、甲状旁腺素(PTH)水平及不良反应发生情况。结果:治疗前,3组患者上述指标比较,差异均无统计学意义(P0.05)。治疗后,3组患者TSH、PTH水平均显著高于同组治疗前,且C组显著高于A、B组;3组患者FT3、FT4、T3、T4、T、E2、LH、FSH、CT、BGP水平均显著低于同组治疗前,且C组显著低于A、B组,差异均有统计学意义(P0.05);但各项指标A、B组间比较,差异均无统计学意义(P0.05)。3组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论:在常规治疗的基础上,甲巯咪唑联合穴位敷贴治疗贴可显著改善甲亢患者的甲状腺功能,性激素水平紊乱和骨代谢异常,且未增加不良反应的发生。
[Abstract]:Objective: to investigate the effect of methimazole combined with acupoint application on hormone level and bone metabolism in hyperthyroidism patients. Methods: 150 patients with hyperthyroidism were randomly divided into group A (n = 50) and group B (n = 50). On the basis of routine therapy, patients in group A were given a starting dose of 2040 mg of methimazole tablets. Once a day, twice a day, if the condition improves after 2 weeks, it will be reduced to 2.5g 10 mg and maintained. If there is no improvement, the patients in group B will be treated with acupoint application and paste 1 patch, 1 hour after breakfast at Zusanli, Sanyinjiao, Shenmen, too Chong, The patients in group C were treated with methimazole tablets (the dosage was the same as group A). The course of treatment was 2 months in group B and group B. the TSH and free TSH were observed before and after treatment in three groups of patients. Triiodothyronine, free tetraiodothyronine, triiodothyronine, triiodothyronine, tetraiodothyronine, testosterone, estradiol, estradiol, luteinizing hormone, luteinizing hormone, follicle stimulating hormone, serum calcitonin, osteocalcin (BGPG), parathyroid. Results: the above indexes were compared among the 3 groups before treatment. After treatment, the levels of TSHP PTH in group C were significantly higher than those in group A and B, and the levels of BGP in group C were significantly higher than those in group C and group C were significantly lower than those in group C and group C, and the levels of BGP in group C and group C were significantly lower than those in group A and group B, and the levels of BGP in group C and group C were significantly lower than those in group A and B, respectively, and the levels of TSHPTH in group C were significantly higher than those in group A (P < 0.05). The difference was statistically significant (P 0.05), but there was no significant difference in the incidence of adverse reactions between the two groups. Conclusion: on the basis of routine treatment, there is no significant difference in the incidence of adverse reactions. The combination of mercapto and acupoint application can significantly improve the thyroid function, sex hormone level disorder and bone metabolism abnormality in patients with hyperthyroidism, and no increase in the occurrence of adverse reactions.
【作者单位】：重庆市人民医院三院院区内分泌科;
【基金】：重庆市卫生和计划生育委员会中医药科技项目(No.ZY20150221)
【分类号】：R581.1

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