硒辅助治疗Graves病伴轻度突眼的临床疗效

发布时间：2018-03-31 04:34

本文选题：硒　切入点：Graves病　出处：《中国现代医学杂志》2017年11期

【摘要】：目的探讨硒联合甲巯咪唑对格雷夫斯病(Graves)病伴轻度突眼患者甲状腺功能、眼球突出度、甲状腺自身抗体及细胞因子的作用。方法选取Graves病伴轻度突眼患者共65例,随机分为对照组、观察组。对照组(30例)口服甲巯咪唑15~30 mg/d,观察组(35例)口服甲巯咪唑15~30 mg/d和硒酵母片100μg,2次/d。分别检测治疗前及治疗后6个月血清甲状腺激素(FT3、FT4)水平、促甲状腺激素(TSH)水平、眼球突出度变化、甲状腺自身抗体(TPOAb、TRAb、TGAb、IgG、IgA和IgM)及细胞因子(IL-2、IL-6)水平。结果治疗6个月后,两组患者FT_3、FT_4、眼球突出度水平、TGAb、TRAb、IgG及IgA水平均较治疗前降低,差异有统计学意义(P0.05)。TSH水平升高,差异有统计学意义(P0.05)。两组TPOAb、IgM、IL-6水平亦较治疗前降低(P0.05),但治疗后两组比较差异无统计学意义(P0.05)。IL-2水平升高(P0.05),但治疗后两组比较差异无统计学意义(P0.05)。结论硒在Graves病及Graves眼病患者中具有抗炎作用,硒辅助治疗Graves病伴轻度突眼具有一定的疗效,值得临床推广应用。
[Abstract]:Objective to investigate the effects of selenium combined with methimazole on thyroid function, exophthalmos, thyroid autoantibodies and cytokines in patients with Graves disease and mild exophthalmos. Methods 65 patients with Graves disease with mild exophthalmos were selected. The patients were randomly divided into two groups: control group (n = 30), control group (n = 30), methimazole 1530 mg / d, observation group (n = 35), methimazole 1530 mg/d and selenium yeast tablet, respectively. The serum thyroid hormone FT3T4 was measured before and 6 months after treatment. Results after 6 months of treatment, the levels of TPO, TPO, TRAb, TGAb, IgA and IgM, and cytokine IL-2IL-6) were decreased in both groups, and the levels of TGAbTRAbIgA and IgA were decreased in both groups after 6 months of treatment. The difference was statistically significant (P 0.05). TSH level was increased. The level of IL-6 in the two groups was also lower than that before treatment, but there was no significant difference between the two groups after treatment. But there was no significant difference between the two groups after treatment. But there was no significant difference between the two groups after treatment. Conclusion selenium in Graves disease and Graves eyes is not significantly different. The disease patients have anti-inflammatory effect, Selenium adjuvant therapy for Graves's disease with mild exophthalmos is effective and worthy of clinical application.
【作者单位】：广州医科大学附属第二医院老年科;广州医科大学附属第二医院内分泌科;广州医科大学附属第二医院放射科;
【分类号】：R581.1;R771.3

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