天津市糖尿病治疗现状和流行病学研究

发布时间：2018-04-04 22:26

本文选题：天津市　切入点：糖尿病　出处：《广东医学》2017年S1期

【摘要】：目的为了有助于临床医师更好地了解哪些降糖方案能让患者依从性更高、更适用于天津市人群,进行天津市糖尿病患者流行病学研究。方法选取天津市糖尿病第一鉴定中心针对天津市糖尿病人群的鉴定工作资料,共收集1 003例。发放并收回患者调查问卷、并对患者糖化血红蛋白、糖耐量以及胰岛功能检测结果等做统计学分析。其中口服降糖药患者470例(口服药组),年龄24~82岁,平均(59.77±9.70)岁,男、女比例为1.07∶1,平均病史(5.86±5.56)年,其糖耐量、胰岛功能检测指标为血清胰岛素水平。共收集注射胰岛素控制糖尿病者533例(胰岛素组),年龄21~49岁,平均(59.30±10.81)岁,男、女比例为1.28∶1,平均病史(10.01±7.87)年,其糖耐量、胰岛功能检测指标为血清C肽水平。结果糖尿病的患病率与年龄关系密切,糖尿病的患病趋势由于这一因素将明显加重,各年龄段人群糖化血红蛋白水平差异无统计学意义(F=0.092,P=0.964)。性别因素中男女平均糖化血红蛋白水平差异有统计学意义,其中男性糖化血红蛋白水平为(7.47±0.72)%,女性为(8.20±0.81)%;口服药组男性糖化血红蛋白水平为(7.28±0.52)%,女性为(8.56±0.66)%,差异有统计学意义;胰岛素组男性糖化血红蛋白水平为(7.63±0.91)%,女性为(7.84±0.85)%,差异无统计学意义。患者体质指数与糖化血红蛋白呈正相关(r=0.074,P=0.024)。两组不同体质指数人群糖化血红蛋白差异无统计学意义。口服药组470例患者总糖耐量水平差异均无统计学意义。各治疗方案间患者糖化血红蛋白情况差异无统计学意义。单纯口服降糖药组糖耐量、血清胰岛素水平基本为胰岛素抵抗患者,表明天津市糖尿病治疗现状合乎规范。结论应用胰岛素治疗的患者其胰岛自身分泌功能尚可,胰岛素分泌尚未相对缺如,效果较满意。糖尿病的发病呈逐渐加重的流行趋势,这与多种因素特别是社会转型和经济发展有关。
[Abstract]:Objective to study the epidemiology of diabetes mellitus patients in Tianjin in order to help clinicians better understand which hypoglycemic regimen can make patients more compliant and more suitable for Tianjin population.Methods 1 003 cases of diabetes mellitus were collected from Tianjin first Diabetes Identification Center.The questionnaire was distributed and collected, and the results of glycosylated hemoglobin, glucose tolerance and islet function were analyzed statistically.Among them, 470 patients with oral hypoglycemic drugs (24 ~ 82 years old, mean 59.77 卤9.70 years old) were given oral hypoglycemic drugs. The ratio of male to female was 1.07: 1, and the mean history was 5.86 卤5.56 years. The glucose tolerance and islet function were measured by serum insulin level.A total of 533 patients (insulin group, age 21 to 49 years, mean 59.30 卤10.81 years) with diabetes mellitus controlled by insulin injection were collected. The ratio of male to female was 1.28: 1, with an average history of 10.01 卤7.87 years. The glucose tolerance and islet function were measured by serum C-peptide level.Results the prevalence rate of diabetes was closely related to age. The prevalence trend of diabetes would be aggravated obviously. There was no significant difference in the level of glycosylated hemoglobin between different age groups.There was statistically significant difference in the average glycosylated hemoglobin level between male and female, among which the male was 7.47 卤0.72, the female was 8.20 卤0.81, the oral drug group was 7.28 卤0.52 and the female was 8.56 卤0.66, the difference was statistically significant.The level of glycosylated hemoglobin in insulin group was 7.63 卤0.91g in male and 7.84 卤0.85 in female.There was a positive correlation between body mass index (BMI) and glycosylated hemoglobin (P 0.024).There was no significant difference in glycosylated hemoglobin between the two groups with different body mass index.There was no significant difference in total glucose tolerance in 470 patients in oral drug group.There was no significant difference in glycosylated hemoglobin among different treatment regimens.The glucose tolerance and serum insulin level in the oral hypoglycemic drug group were basically insulin resistance patients, which indicated that the current status of diabetes treatment in Tianjin was in accordance with the standard.Conclusion the islet autocrine function of the patients treated with insulin is fairly good, and the insulin secretion is not yet relatively absent, and the effect is satisfactory.The prevalence of diabetes is gradually increasing, which is related to many factors, especially social transformation and economic development.
【作者单位】：天津市第一中心医院内分泌科天津医科大学卫生部激素与发育重点实验室;
【基金】：国家自然科学基金资助项目(编号:31470925) 卫生部激素与发育重点实验室开放课题代谢性疾病基础与临床协同创新中心科学基金项目(编号:2014DX01) 天津市卫生局科技基金项目(编号2013KZ025)
【分类号】：R587.1

【相似文献】