肥胖与绝经期女性居民骨密度的相关性研究

发布时间：2018-04-05 13:28

本文选题：女性　切入点：绝经期　出处：《四川大学学报(医学版)》2017年01期

【摘要】：目的利用不同人体测量参数研究成都地区50岁以上绝经期女性居民肥胖与骨质疏松的相关性。方法采集在四川大学华西医院进行健康体检的50岁以上绝经期女性受检者的临床资料,测量和计算不同人体测量指标。使用MetriScan手掌骨密度测量仪进行骨密度测定,并根据骨密度T值将受试者分为3组(正常骨密度组、骨量减少组和骨质疏松组)并进行相关统计分析。结果研究纳入4 938例成都地区50岁以上绝经期女性,肥胖症(BMI28kg/m2)检出率为8.55%。骨质疏松组的体质量指数(BMI)、身体形态指数(ABSI)、体质量、腰围、臀围、身高等均与骨量减少与正常骨密度组差异有统计学意义(P0.01)。经过对年龄调整后,T值与身高、体质量、腰围、臀围、腰臀比(WHR)、腰高比(WHtR)、体圆柱指数(BRI)呈正相关(P0.05)。腰围和BMI与骨质疏松的ROC曲线的曲线下面积(AUC)最大,分别为0.540和0.568。结论对于绝经期女性,肥胖与骨质疏松可能存在一定的负相关。但这种负相关的临床意义需要更多基于人群的大样本纵向研究进一步验证。
[Abstract]:Objective to study the correlation between obesity and osteoporosis in menopausal women over 50 years old in Chengdu by using different anthropometric parameters.Methods the clinical data of postmenopausal female subjects over 50 years old who underwent health examination in Huaxi Hospital of Sichuan University were collected, and different anthropometric indexes were measured and calculated.Bone mineral density (BMD) was measured by MetriScan palmar BMD instrument. The subjects were divided into 3 groups according to BMD T value (normal bone density group, bone mass reduction group and osteoporosis group) and related statistical analysis was carried out.Results the detection rate of obesity in 4938 menopausal women over 50 years old in Chengdu was 8.55.After age adjustment, there was a positive correlation between T value and height, body mass, waist circumference, hip circumference, waist-to-hip ratio (WHR), waist-to-hip ratio (WHR), waist / height ratio (WHR), and column index (BRI).The maximum area under the ROC curve of waist circumference and BMI and osteoporosis was 0.540 and 0.568 respectively.Conclusion there may be a negative correlation between obesity and osteoporosis in menopausal women.However, the clinical significance of this negative correlation needs to be further verified by a large sample of longitudinal studies based on population.
【作者单位】：四川大学华西医院全科医学科;四川大学华西医院健康管理中心;四川大学华西医院内分泌代谢科;四川大学华西医院中国循证医学中心;
【基金】：国家自然科学基金(No.81400811和No.21534008)资助
【分类号】：R589.2

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