小乌桂颗粒剂联合来氟米特治疗强直性脊柱炎的临床研究

发布时间：2018-04-05 18:51

本文选题：强直性脊柱炎　切入点：小乌桂颗粒剂　出处：《中药材》2015年05期

【摘要】：目的:评价小乌桂颗粒剂联合来氟米特(LEF)治疗强直性脊柱炎(AS)的临床疗效和安全性。方法:2013年02月~2014年02月南方医院中医风湿专科64例强直性脊柱炎(寒湿痹阻型)患者随机分为小乌桂颗粒剂联合LEF治疗组32例(观察组),LEF治疗组32例(对照组),疗程为12周,采用国际AS评价工作组制定的ASAS20、ASAS40标准、中医证候疗效评价标准及强直性脊柱炎疾病活动评分(ASDAS-CRP)、Bath强直性脊柱炎病情活动指数(BASDAI)、Bath强直性脊柱炎功能指数(BASFI)、脊柱痛评分、病人总体评价(PGA)、枕墙距、胸廓活动度、Schober、指地距、C反应蛋白(CRP)及血沉(ESR)为疗效评价指标,并观察两组治疗过程中出现的不良反应。结果:经治疗12周后,观察组患者的中医证候积分、ASDAS-CRP、BASDAI、脊柱痛评分、PGA、ESR及CRP与对照组比较显著降低(P0.05),中医证候疗效总有效率及ASAS20、ASAS40达标率显著升高(P0.05);而体格检查方面,12周时除了观察组指地距与治疗前比较有统计学意义(P0.01);其余体征如枕墙距、胸廓活动度、Schober在治疗前后比较差异均无统计学意义(P0.05)。不良反应发生例次对照组为4例,观察组为2例,两组比较差异无统计学意义。结论:小乌桂颗粒剂联合LEF治疗AS患者,在炎症和病情的控制及中医证候的改善优于LEF,且治疗过程中不良反应较少,具有较好的临床应用前景。
[Abstract]:Objective: to evaluate the efficacy and safety of Xiaowugui granule combined with leflunomide in the treatment of ankylosing spondylitis (ASA).Methods: from February 2013 to February 2014, 64 patients with ankylosing spondylitis treated with Xiaowugui granule combined with LEF were randomly divided into two groups: control group (control group, n = 32).Using the ASAS20 ASAS40 standard developed by the International as Evaluation working Group, the evaluation criteria of TCM syndromes and the activity score of ankylosing spondylitis (ASDAS-CRPU) Bath ankylosing spondylitis activity index (BASDAI), Bath ankylosing spondylitis function index (BASFII), spinal pain score,The overall evaluation of patients with PGA, occipital-wall distance, thoracic activity, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were used to evaluate the efficacy of the two groups. The adverse reactions of the two groups during the treatment were observed.Results: after 12 weeks of treatment,Compared with before treatment, there was statistical significance (P 0.01), other signs such as occipital-wall distance,There was no significant difference in the thoracic activity of Schober before and after treatment (P 0.05).There were 4 cases in the control group and 2 cases in the observation group. There was no significant difference between the two groups.Conclusion: Xiaowugui granule combined with LEF in the treatment of as patients, in inflammation and disease control and the improvement of TCM syndromes is better than Lef, and the treatment process has fewer adverse reactions, and has a good clinical application prospects.
【作者单位】：南方医科大学中医药学院;南方医科大学南方医院;
【基金】：广东省自然科学基金(S2012010009164) 广东省“211”工程三期重点学科建设项目
【分类号】：R593.23

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