亚临床甲状腺功能减退与冠心病及冠脉病变严重程度的相关性

发布时间：2018-04-09 08:04

本文选题：亚临床甲状腺功能减退　切入点：冠心病　出处：《中国老年学杂志》2017年23期

【摘要】：目的探讨亚临床甲状腺功能减退(SCH)与冠心病及冠脉病变严重程度的相关性。方法行冠状动脉造影患者124例,根据甲状腺功能分为SCH组52例及甲状腺功能正常组(EU组)72例,比较两组临床资料、冠状动脉造影结果、Gensini评分,采用多因素Logistic回归分析SCH水平与冠心病的关系,并采用简单线性回归分析法分析促甲状腺激素(TSH)水平与冠脉严重程度的关系。结果两组年龄、体质指数(BMI)、高血压病史、糖尿病史、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平比较均无统计学差异(P0.05),SCH组女性占比、TSH水平、冠心病发病率及Gensini评分均高于EU组,而吸烟史占比低于EU组(P0.05)。多因素Logistic回归分析显示,SCH是冠心病发生的独立危险因素(P0.05);简单线性回归分析显示,TSH水平与Gensini评分呈正相关(P0.05)。结论 SCH是冠心病的危险因素之一,TSH与冠状动脉病变严重程度呈正相关。
[Abstract]:Objective to investigate the relationship between subclinical hypothyroidism and severity of coronary artery disease and coronary artery disease.Methods 124 patients with coronary arteriography were divided into SCH group (52 cases) and normal thyroid function group (72 cases) according to thyroid function.Multivariate Logistic regression analysis was used to analyze the relationship between SCH level and coronary artery disease, and simple linear regression analysis was used to analyze the relationship between thyroid stimulating hormone (TSH) level and the severity of coronary artery disease.Results there was no significant difference in age, BMI, history of hypertension, history of diabetes, triglyceride TGG, total cholesterol TCU, HDL-C, LDL-C of low density lipoprotein cholesterol (LDL-C) in the two groups.The incidence and Gensini score of coronary heart disease were higher than that of EU group, but the proportion of smoking history was lower than that of EU group (P 0.05).Multivariate Logistic regression analysis showed that Sch was an independent risk factor for coronary heart disease (P 0.05), and simple linear regression analysis showed that there was a positive correlation between TSH level and Gensini score (P 0.05).Conclusion SCH is one of the risk factors of coronary artery disease and has a positive correlation with the severity of coronary artery disease.
【作者单位】：苏州大学附属第三医院心内科;
【基金】：江苏省自然科学基金项目(No.BK20140249)
【分类号】：R541.4;R581.2

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