血脂与糖代谢异常关系的队列研究

发布时间：2018-04-09 13:52

本文选题：血脂　切入点：糖尿病前期　出处：《苏州大学》2015年硕士论文

【摘要】：研究背景目前国内尚未见有关大样本的蒙古族人群血脂与糖代谢异常发病关系的前瞻性研究的相关报道。研究目的探讨血脂指标(包括总胆固醇、甘油三酯、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇4个指标)与糖尿病前期、糖尿病及糖代谢异常之间的关系。研究对象与方法1.基线调查:2002-2003年,选择内蒙古科左后旗和奈曼旗两个乡32个行政村为研究地点,选择20岁及以上蒙古族居民共2589人为研究对象,签署知情同意书后开展问卷调查、体格检查、血压测量和血标本的采集;并且由经过严格培训的实验室人员进行血脂和胰岛素等指标的检测。2.随访调查:2013-2014年对基线调查时20-65岁之间血糖正常(空腹血糖6.1mmol/L)的研究对象进行随访调查,内容包括:收集人口统计学、疾病史和生活方式等传统危险因素资料;进行体格检查;检测空腹血糖和进行口服葡萄糖耐量试验。3.统计分析:采用Epidata3.1软件建立数据库,所有调查表经过双录入后进行核对,应用SAS 9.2软件进行统计分析,检验水准α设为0.05。研究结果共有1760人纳入数据分析,其中血糖正常者1090例,糖尿病前期者513例,糖尿病患者157例。1.糖尿病的累积发病率为8.92%,发病密度为81.97/万人年;糖尿病前期的累积发病率为29.15%,发病密度为267.85/万人年;糖代谢异常的累积发病率为38.07%,发病密度为349.82/万人年。2.蒙古族人群糖尿病前期、糖尿病和糖代谢异常的发病率无明显性别差异(均P0.05)。在30,30-39,40-49以及≥50岁的人群中,糖尿病前期和糖代谢异常的累积发病率在男性、女性以及总人群中均随着年龄的增加而增加(均P0.05);糖尿病的累积发病率在女性和总人群中均随着年龄的增加而增加(均P0.05)。3.与血糖正常者相比,糖尿病前期者基线TC、TG和LDL-C水平均较高;与血糖正常者相比,糖尿病患者和糖代谢异常者TC、TG和LDL-C水平均较高,HDL-C水平较低;与糖尿病前期者相比,糖尿病患者的TG水平较高,HDL-C水平较低。4.总人群中,经多因素调整后,与TG
[Abstract]:Background at present, there are no prospective reports on the relationship between blood lipids and glycometabolism in large samples of Mongolian population.Objective to investigate the relationship between serum lipids (including total cholesterol, triglyceride, low density lipoprotein cholesterol and high density lipoprotein cholesterol) and diabetes mellitus and abnormal glucose metabolism.Object and method 1.The baseline survey: in 2002-2003, 32 administrative villages of Kezuohou Banner and Naiman Banner of Inner Mongolia were selected as the study sites, and 2589 Mongolian residents aged 20 and above were selected as the research subjects. After signing the informed consent letter, they conducted a questionnaire survey and a medical examination.Blood pressure was measured and blood samples were collected, and blood lipids and insulin were measured by trained laboratory personnel. 2. 2.Follow-up survey: in 2013-2014, subjects aged 20-65 years with normal blood glucose (fasting blood glucose 6.1 mmol / L) were followed up in the baseline survey, including collecting data on traditional risk factors, such as demography, history of disease and lifestyle;Fasting blood glucose and oral glucose tolerance test. 3.Statistical analysis: Epidata3.1 software was used to establish the database, all the questionnaires were checked after double input, and the SAS 9.2 software was used for statistical analysis. The test level was set to 0.05.A total of 1760 people were included in the data analysis, including 1090 patients with normal blood glucose, 513 patients with prediabetes and 157 patients with diabetes.The cumulative incidence of diabetes was 8.92, the incidence density was 819.7 / 10, the prediabetic cumulative incidence was 29.155.The cumulative incidence of abnormal glucose metabolism was 38.07, and the incidence density was 349.82 / 10 000.There was no significant difference in the incidence of diabetes mellitus and abnormal glucose metabolism in Mongolian population (all P 0.05).The cumulative incidence of prediabetes and abnormal glucose metabolism was found in men aged 30 to 39 years and older than 50 years.Compared with normal blood glucose, the baseline TCTG and LDL-C levels were higher in prediabetic patients, higher in diabetic patients and abnormal glucose metabolism patients, and lower in prediabetic patients.The TG level of diabetic patients is higher and HDL-C level is lower. 4. 4.Among the total population, after multifactorial adjustment, the relationship between TG and TG
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R587.1

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