宣痹通络汤加减治疗糖尿病周围神经病变的临床观察

发布时间：2018-04-09 16:23

本文选题：糖尿病周围神经病变　切入点：宣痹通络汤　出处：《新疆医科大学》2017年硕士论文

【摘要】：目的:观察宣痹通络汤加减治疗糖尿病周围神经病变痰瘀阻络证的临床疗效。方法:本研究是临床疗效研究,将72例研究对象分为对照组35例和治疗组37例,两组均予基础治疗,另对照组予甲钴胺片治疗,治疗组在对照组的基础上加用宣痹通络汤口服。治疗8周后比较两组治疗前后震动感觉阈值(VPT)、踝肱指数(ABI)、中医证候积分、多伦多临床评分(TCSS)等指标的变化,评价宣痹通络汤的疗效。结果:(1)VPT:两组治疗后治疗组左右足VPT的改善优于对照组(P0.05)。(2)ABI:两组治疗后治疗组左右腿ABI的改善与对照组相比差异无统计学意义(P0.05)。(3)中医证候积分:两组治疗后与治疗前相比中医证候积分均明显下降(P0.05),组间比较肢体麻木、头身困重、倦怠乏力三个症状积分改善治疗组优于对照组(P0.05)。(4)中医症状综合疗效:治疗组总有效率为81.1%,对照组为62.9%,治疗组总有效率优于对照组(P0.05)。(5)TCSS:治疗后组间比较,治疗组症状评分、TCSS总分的下降优于对照组(P0.05)。结论:宣痹通络汤联合甲钴胺片治疗DPN在改善中医证候积分、TCSS、VPT方面疗效优于单纯甲钴胺片治疗。
[Abstract]:Objective: to observe the clinical effect of Xuanbi Tongluo decoction on phlegm and blood stasis syndrome of diabetic peripheral neuropathy.Methods: 72 cases were divided into control group (n = 35) and treatment group (n = 37). Both groups were treated with basic treatment, the control group were treated with mecobalamin tablets, the treatment group was treated with Xuantongbi decoction on the basis of the control group.After 8 weeks of treatment, the changes of vibration sensation threshold, ankle brachial index (ABI), TCM syndromes score, Toronto clinical score and TCSSwere compared between the two groups before and after treatment, and the curative effect of Xuanbi Tongluo decoction was evaluated.Results: after treatment, the improvement of left and right foot VPT in the treatment group was better than that in the control group (P 0.05). There was no significant difference between the treatment group and the control group in the improvement of left and right leg ABI.Compared with TCM syndromes, the scores of TCM syndromes decreased significantly (P 0.05), and the limbs were numb between groups.The total score of TCSS in the treatment group was lower than that in the control group (P 0.05).Conclusion: Xuanbi Tongluo decoction combined with mecobalamin tablet is superior to mecobalamin tablets in the treatment of DPN.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R587.2

【参考文献】