骨关节病变及骨折患者围术期骨代谢标志物检测及骨密度变化

发布时间：2018-04-10 15:34

本文选题：骨质疏松 + 骨质疏松性骨折　；参考：《中国组织工程研究》2016年35期

【摘要】：背景:骨密度反映的是相对长时间内的骨量情况,是一个静态参数,如果要了解骨代谢的动态变化过程,需评估骨代谢标志物。目的:探讨脊柱和关节退变以及骨质疏松性骨折患者围术期骨代谢标志物及骨密度变化。方法:应用计算机检索Pub Med数据库和万方数据库,中文检索词为"骨代谢标志物;骨密度;血液;尿液"英文检索词为"bone metabolic markers;Bone mineral density;Serum;urine",纳入文献时间限定为2005至2016年,按纳入排除标准选择29篇文献进行分析。结果与结论:目前临床常用的骨形成标志物主要包括骨碱性磷酸酶、骨钙素、Ⅰ型前胶原N末端前肽、Ⅰ型前胶原C末端前肽等,骨吸收标志物主要包括抗酒石酸酸性磷酸酶、Ⅰ型胶原N端交联肽、Ⅰ型胶原C端交联肽、脱氧吡啶啉、吡啶啉、羟脯氨酸等。脊柱和关节退变以及骨质疏松性骨折患者围术期骨密度变化不大,骨吸收标志物水平增高,提示骨吸收过程活跃;而骨形成标志物在骨折患者围术期增高,说明骨折围术期存在新骨形成;在骨退行性变患者围术期骨形成标志物降低,骨形成过程受抑制。综合看,骨关节病变及骨折患者围术期的骨吸收过程加剧更为明显,可能进一步加重患者骨质疏松程度,应进行正规的抗骨质疏松治疗。
[Abstract]:Background: bone density reflects the relative bone mass, a long time, is a static parameter, if you want to understand the dynamic changes of bone metabolism, to evaluate the markers of bone metabolism. Objective: To investigate the spinal and joint degeneration and osteoporotic fracture during perioperative period in patients with bone metabolic changes of markers and bone mineral density. Application: computer retrieval Pub Med database and Wanfang database, the key words of "Chinese markers of bone metabolism; bone mineral density; blood; urine English" key words "bone metabolic markers Bone mineral; density; Serum; urine, the time limit for the literature from 2005 to 2016, according to the inclusion and exclusion criteria 29 articles were analyzed. Results and conclusion: the current clinical markers of bone formation include bone alkaline phosphatase, osteocalcin, procollagen N terminal peptide of procollagen C terminal peptide, markers of bone resorption. The tartrate resistant acid phosphatase, type I collagen N terminal telopeptide of type I collagen, C terminal telopeptide, deoxypyridinoline, DPD, hydroxyproline. The spine and joint degeneration and osteoporotic fracture patients during operation period little changes of bone density, bone resorption markers increased, suggesting that the bone resorption process is active; the markers of bone formation in patients with increased perioperative fracture, indicating the perioperative period of new bone formation in bone fracture; degeneration of perioperative marker of bone formation decreased, bone formation was inhibited. In general, bone and joint disease and fracture in patients with bone resorption increased more obviously that may further increase the degree of osteoporosis patients, should be anti osteoporosis treatment regular.

【作者单位】：锦州医科大学附属第三医院临床检验中心;
【分类号】：R580;R687

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