支气管哮喘合并肺结核患者脑源性神经营养因子和神经激肽A表达对预后的影响分析

发布时间：2018-04-11 11:06

本文选题：支气管哮喘 + 肺结核　；参考：《中华医院感染学杂志》2017年04期

【摘要】：目的探究支气管哮喘合并肺结核患者脑源性神经营养因子(BDNF)和神经激肽A(NKA)表达对预后的影响,以便于更好地监测患者病情进展,改善患者预后,提高患者生活质量。方法随机选取2014年1月-2015年12月医院收治55例支气管哮喘合并肺结核患者为观察组对象,另选取30名在医院体检的健康成人为对照组,观察并记录两组受试者治疗前后BDNF、NKA、第一秒用力呼吸量(FEV1)和呼气峰值(PEF)变化情况,分析比较。结果哮喘急性期患者BDNF水平显著高于哮喘缓解期患者和对照组,治疗后,缓解期和急性期支气管哮喘患者BDNF均下降,与治疗前比较差异有统计学意义(P0.05);支气管哮喘缓解期患者NKA显著高于对照组,而哮喘急性期患者显著高于缓解期患者,两组比较差异有统计学意义(P0.05),治疗后,均有明显降低,较治疗前差异有统计学意义(P0.05);治疗后,两组患者FEV1和PEF等肺功能指标明显改善,较治疗前差异有统计学意义(P0.05)。结论支气管哮喘患者体内NKA和BDNF含量较正常人显著升高,有利于疾病早期诊断和监测,便于控制病情发展,预后较好。
[Abstract]:Objective to investigate the effect of the expression of brain-derived neurotrophic factor BDNFand neurokinin Agna on the prognosis in patients with bronchial asthma complicated with pulmonary tuberculosis, so as to better monitor the progress of the disease, improve the prognosis and improve the quality of life of the patients.Methods from January 2014 to December 2015, 55 patients with bronchial asthma complicated with pulmonary tuberculosis were randomly selected as observation group and 30 healthy adults as control group.To observe and record the changes of BDNFN NKA, FEV1 and PEF1 before and after treatment in two groups, and to analyze and compare the changes of BDNF NKAA, FEV1 and PEF1 before and after treatment.Results the level of BDNF in patients with acute asthma was significantly higher than that in patients with asthma in remission and control groups. After treatment, BDNF decreased in patients with asthma in remission and acute asthma.The NKA of patients with bronchial asthma in remission stage was significantly higher than that in control group, while that in acute stage of asthma was significantly higher than that in remission stage. The difference between the two groups was statistically significant (P 0.05).After treatment, the pulmonary function indexes such as FEV1 and PEF were significantly improved in the two groups, and the difference was statistically significant compared with that before treatment.Conclusion the levels of NKA and BDNF in patients with bronchial asthma are significantly higher than those in normal subjects, which is beneficial to early diagnosis and monitoring of the disease, facilitate the control of the development of the disease and have a good prognosis.
【作者单位】：海南医学院附属医院呼吸内科;
【基金】：47309066)" target="_blank">海南省科技厅基金资助项目(琼卫科教函<2009>47309066)
【分类号】：R521;R562.25

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