黄芪注射液联合硫辛酸注射液治疗糖尿病足的效果

发布时间：2018-04-11 19:25

本文选题：糖尿病足 + 黄芪注射液　；参考：《中药药理与临床》2017年02期

【摘要】：目的:观察黄芪注射液联合硫辛酸注射液治疗糖尿病足的临床疗效。方法:120例糖尿病足患者,采用随机数字表法分为对照组(硫辛酸注射液组)和治疗组(硫辛酸注射液联合黄芪注射液组),每组各60例,两组疗程均为28d。比较两组治疗后临床效果、血糖变化、腓总神经和腓肠神经的运动神经传导速度(MNCV)和感觉神经传导速度(SNCV);血液流变学变化情况;血清中肿瘤细胞坏死因子(TNF-α),白细胞介素-6(IL-6),血管内皮细胞生长因子(VEGF)指标变化。结果:治疗28d后,治疗组总有效率显著高于对照组;治疗组糖化血红蛋白值较对照组显著降低;治疗组腓总神经和腓肠神经的运动神经传导速度(MNCV)和感觉神经传导速度(SNCV)显著快于对照组;治疗组血液流变学指标显著低于对照组;两组血清中TNF-α、IL-6浓度显著降低,VEGF浓度显著升高,且治疗组上述生化指标改善程度显著优于对照组。结论:黄芪注射液联合硫辛酸注射液进行糖尿病足治疗,取得了良好的治疗效果。
[Abstract]:Objective: to observe the clinical effect of astragalus injection combined with lipoic acid injection on diabetic foot.Methods 120 patients with diabetic foot were randomly divided into two groups: control group (lipoic acid injection group) and treatment group (Astragalus membranaceus injection group) with 60 cases in each group. The course of treatment in both groups was 28 days.The changes of blood glucose, motor nerve conduction velocity (MNCVV) and sensory nerve conduction velocity (SNCVV) of common peroneal nerve and sural nerve were compared between the two groups.The changes of TNF- 伪, IL-6 and VEGF in serum were observed.Results: after 28 days of treatment, the total effective rate in the treatment group was significantly higher than that in the control group, and the glycosylated hemoglobin value in the treatment group was significantly lower than that in the control group.The motor nerve conduction velocity (MNCVV) and sensory nerve conduction velocity (SNCVV) of the common peroneal nerve and sural nerve in the treatment group were significantly faster than those in the control group, and the hemorheological indexes in the treatment group were significantly lower than those in the control group.The concentration of TNF- 伪 IL-6 in serum of both groups decreased significantly and the concentration of VEGF increased significantly, and the improvement of the above biochemical indexes in the treatment group was significantly better than that in the control group.Conclusion: Astragalus injection combined with lipoic acid injection is effective in treating diabetic foot.
【作者单位】：河南中医药大学第三附属医院内分泌科;
【基金】：河南省自然科学基金项目(No:5300214)
【分类号】：R587.2

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