不同年龄组男性人群甲状腺功能与骨密度及骨微结构的相关性

发布时间：2018-04-12 22:34

本文选题：甲状腺功能 + 骨密度　；参考：《南京医科大学学报(自然科学版)》2017年12期

【摘要】：目的 :研究不同年龄组男性人群中正常范围内的甲状腺功能与骨密度及新型骨微结构评估指标骨小梁评分的相关性。方法:191例60岁和97例≥60岁且符合入选标准的男性体检者,检测一般生化指标、游离三碘甲状腺原氨酸(free triiodothyronine,FT3)、游离甲状腺素(free thyroxine,FT4)、促甲状腺素(thyroid stimulating hormone,TSH),采用双能X线骨密度仪检测股骨颈、总髋部及腰椎骨密度(bone mineral density,BMD),运用TBS i Nsight软件分析得出骨小梁评分(trabecular bone score,TBS)。结果 :在两个年龄组,TBS与各部位BMD均呈正相关;在青中年男性人群中,FT3水平不仅与总髋部BMD、腰椎BMD呈负相关,而且与腰椎TBS呈负相关,且较BMD更明显;在老年男性人群中,股骨颈BMD、总髋部BMD及TBS与年龄呈负相关,而与甲状腺功能无相关性。结论:TBS和各部位BMD有良好的相关性;在甲状腺功能正常的青中年男性人群中,正常上限的FT3可能导致骨量下降和骨微结构破坏。而在甲状腺功能正常的老年男性人群中,较之于甲状腺功能,年龄对骨密度及骨微结构的不利影响更大。
[Abstract]:Aim: to study the correlation between normal thyroid function and bone mineral density (BMD) and bone trabecula score (BTS) in men of different age groups.Methods 191 male subjects over 60 years old and 97 male subjects over 60 years old who met the selection criteria were examined for general biochemical parameters.Results: there was a positive correlation between BMD and BMD in two age groups, and the level of FT3 was negatively correlated not only with total hip, lumbar BMD, but also with TBS of lumbar vertebrae, and was more significant than that of BMD.BMD and TBS of total hip were negatively correlated with age, but not correlated with thyroid function.Conclusion there is a good correlation between BMD and BMD in different parts, and the normal upper limit FT3 may lead to the decrease of bone mass and the destruction of bone microstructure in young and middle-aged men with normal thyroid function.Age had more adverse effects on bone mineral density and bone microstructure than thyroid function in elderly men with normal thyroid function.
【作者单位】：南京医科大学第一附属医院老年医学科;南京医科大学第一附属医院内分泌科;
【基金】：国家自然科学基金青年基金(81400856)
【分类号】：R580

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