同型半胱氨酸对血管型白塞氏病动静脉血栓形成的危险性的荟萃分析

发布时间：2018-04-13 00:01

  本文选题：同型半胱氨酸 + 白塞氏病　； 参考：《新疆医科大学》2015年硕士论文

【摘要】：目的白塞氏病(Behcet Disease)即贝赫切特综合征为病因尚不明确的多系统、炎性、复发性、慢性血管性疾病。同型半胱氨酸(HCY)对动脉血栓和静脉血栓是独立危险因素。在白塞氏病患者中同型半胱氨酸血症与动、静脉血栓形成之间关联已被开始研究。但此关联仅基于与相互矛盾小研究的结果,为了克服这些局限性,我们系统地评价了白塞氏病患者血浆同型半胱氨酸(HCY)水平与动静脉血栓形成间的关联性。方法检索pubmed、EMBASE、Cochrane Library、web of science,CNKI等外文数据库上所有关于白塞氏病合并动静脉血栓形成的研究。按照纳入排除标准纳入文献,并采用RevMan5.2.0软件进行统计学分析。结果最终纳入11个研究(n=727)。Meta分析结果显示：同型半胱氨酸血症在血栓组较无血栓组普遍[OR=2.61,95%CI(1.46～4.67,P=0.001)],血栓组同型半胱氨酸的平均水平显著高于无血栓组[MD=2.99,95%CI(1.81～4.16,P=0.00001)]。结论我们的研究结果表明,高的血浆同型半胱氨酸在BD患者中增加动静脉血栓形成的风险。
[Abstract]:Objective Behcet Disease- Behcet disease (Behcet Disease), Behcet Disease, or Behcet Disease, is a multisystem, inflammatory, recurrent and chronic vascular disease with unclear etiology.Homocysteine HCY is an independent risk factor for arterial and venous thrombosis.The association between homocysteinemia and arteriovenous thrombosis has been studied in patients with Behcet's disease.In order to overcome these limitations, we systematically evaluated the association between plasma homocysteine homocysteine (HCY) levels and arteriovenous thrombosis (AVT) in patients with Behcet's disease.Methods all the studies on BACE complicated with arteriovenous thrombosis were searched in the database of pubmedmedus EMBASE Cochrane Library web of scienceof CNKI and so on.According to the inclusion exclusion criteria to include the literature, and RevMan5.2.0 software for statistical analysis.Conclusion our results suggest that high plasma homocysteine increases the risk of arteriovenous thrombosis in BD patients.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R597.7
，

本文编号：1742001