维生素D口服辅助治疗2型糖尿病伴轻度认知功能障碍临床观察

发布时间：2018-04-13 06:48

  本文选题：型糖尿病 + 轻度认知障碍　； 参考：《山东医药》2017年27期

【摘要】：目的观察维生素D口服辅助治疗2型糖尿病伴轻度认知功能障碍的效果。方法 2型糖尿病伴轻度认知功能障碍患者60例,随机分为对照组和治疗组各30例。对照组在饮食指导、生活方式指导、运动和血糖控制的基础上口服奥拉西坦胶囊800 mg/次,3次/d,连续服用24周。治疗组在对照组基础上,口服维生素D滴剂(胶囊型)2粒,连续服用24周。两组分别于治疗前和治疗4、12、24周时检测血清25-羟基维生素D_3[25(OH)D_3]浓度,采用蒙特利尔认知评价量表(MoCA)评分评价认知功能,检测空腹血糖(FPG)、空腹胰岛素(FPI)、糖化血红蛋白(HbA_(1c))并计算胰岛素抵抗指数(HOMA-IR),用药期间观察药物不良反应和低血糖发生情况。结果治疗组治疗4、12、24周时血清25(OH)D_3均高于治疗前(P均0.05),且治疗12、24周时血清25(OH)D_3水平高于对照组(P均0.01)。治疗组治疗12、24周时MoCA评分高于治疗前(P均0.01),治疗24周时MoCA评分高于对照组(P0.05)。治疗组治疗12、24周时FPG、HbA_(1c)低于治疗前,治疗24周时FPI、HOMA-IR低于治疗前(P均0.05);治疗组治疗24周时FPG、FPI、HbA_(1c)、HOMA-IR均低于对照组(P均0.05)。两组患者治疗过程中血常规、肝肾功能、电解质、尿常规等均未出现明显异常。治疗组2例出现食欲减退和便秘症状,均在数日后自行缓解。两组均未出现低血糖症状。结论维生素D口服辅助治疗2型糖尿病伴轻度认知功能障碍可改善患者的认知功能,并有助于控制血糖和纠正胰岛素抵抗,用药安全性较好。
[Abstract]:Objective To observe the effect of oral vitamin D assisted with mild cognitive dysfunction in type 2 diabetes therapy. Methods of type 2 diabetes patients with mild cognitive impairment in patients with 60 cases, were randomly divided into control group and treatment group with 30 cases in each group. The control group in the diet guidance, life guidance, exercise and blood glucose control on oral administration of Oxiracetam Capsules 800 mg/ times. 3 /d, administered for 24 weeks. The treatment group on the basis of the control group, oral vitamin D drops (capsule) 2 capsules administered for 24 weeks. The two groups respectively before treatment and 4,12,24 weeks serum 25- hydroxyvitamin D_3[25 (OH) D_3] concentration, using the Montreal cognitive assessment scale (MoCA) the score of cognitive function evaluation, fasting blood glucose (FPG), fasting insulin (FPI), glycosylated hemoglobin (HbA_ (1c)) and insulin resistance index (HOMA-IR), medication during the observation of adverse reactions and hypoglycemia drugs. 鍐，

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