老年支气管哮喘患者PAI-1、STAT2基因多态性分析

发布时间：2018-04-13 08:39

本文选题：纤溶酶原激活物抑制剂 + 信号转导子及转录激活因子　；参考：《山东医药》2017年38期

【摘要】：目的探讨老年支气管哮喘(简称哮喘)患者纤溶酶原激活物抑制剂1(PAI-1)、信号转导子及转录激活因子2(STAT2)基因多态性。方法选择80例老年哮喘患者(哮喘组)及80例老年健康查体者(对照组)。采用PCR扩增方法检测两组静脉血PAI-1基因启动子区基因型(4G/4G型、5G/5G型、4G/5G型)和STAT2基因型(CG型、GG型、CC型)。结果哮喘组PAI-1基因4G/4G、4G/5G、5G/5G基因型及4G等位基因分别为33、36、11、102例,对照组分别为17、41、22、75例,除4G/5G基因型外,其他指标两组相比P均0.05。哮喘组STAT2基因CC、CG、GG基因型及C等位基因分别为0、7、73、7例,对照组分别为0、3、77、3例,两组相比P均0.05。哮喘组PAI-1基因型为4G/4G且STAT2基因型为GG例数高于对照组(P均0.05)。PAI-1基因型为4G/4G且STAT2基因型为GG发生哮喘的相对风险OR=2.22,95%CI=1.1~4.5,P0.05。结论 PAI-1基因4G/4G基因型是老年哮喘发病的易感基因型;STAT2基因CG多态性与老年哮喘无明显关联;PAI-1基因4G/4G基因型和STAT2基因GG基因型在老年哮喘发病上具有协同作用。
[Abstract]:Objective to investigate the polymorphisms of plasminogen activator inhibitor 1 (PAI-1), signal transductor and activator of transcription (2) STAT2 gene in elderly patients with bronchial asthma (Asthma).Methods 80 elderly asthmatic patients (asthma group) and 80 elderly healthy subjects (control group) were selected.PCR amplification method was used to detect 4G / 4G / 5G / 5G genotype of PAI-1 gene promoter region and 4G / 5G / 5G genotype of STAT2 genotype respectively.Results in asthmatic group, 4G / 4G / 4G / 5G / 5G / 5G / 5G / 5G genotype and 4G allele were 33-3611102 cases, respectively, compared with 1741D 2275 cases in control group. Except for 4G/5G genotype, the two groups were compared with each other (P 0.05).In asthma group, the genotype and C allele of STAT2 gene CCGG and C allele were 0 7 and 73%, respectively, compared with 3 cases in control group (P < 0 05).The relative risk of asthma with PAI-1 genotype (4G/4G) and STAT2 genotype (GG) was higher than that of control group (P < 0.05). Both 0.05).PAI-1 genotype and STAT2 genotype were 4G/4G and STAT2 genotype, respectively.Conclusion the 4G/4G genotype of PAI-1 gene is the susceptible genotype of asthma in the elderly. The CG polymorphism of STAT2 gene has no significant association with the 4G/4G genotype of PAI-1 gene and the GG genotype of STAT2 gene in the pathogenesis of senile asthma.
【作者单位】：潍坊医学院;潍坊市人民医院;
【分类号】：R562.25

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