糖尿病视网膜病变患者血清脂蛋白相关磷脂酶A2水平变化及其相关因素分析

发布时间：2018-04-14 02:35

  本文选题：糖尿病视网膜病变 + 血脂　； 参考：《中国糖尿病杂志》2017年08期

【摘要】：目的观察不同时期DR患者血清脂蛋白相关磷脂A2(Lp-PLA2)水平,并进行相关因素分析。方法 160例T2DM患者经眼底照相结果分为无糖尿病视网膜病变(NDR)组、非增殖期糖尿病视网膜病变(NPDR)组、增殖期糖尿病视网膜病变(PDR)组。分别测定FPG、TG、血清Lp-PLA2、血管内皮生长因子(VEGF)水平;对影响血清Lp-PLA2水平的因素进行多重线性回归分析。结果PDR和NPDR组血清Lp-PLA2[(180.90±48.71)vs(153.70±40.61)vs(127.01±37.64)μg/L]、VEGF[(170.34±35.47)vs(146.16±36.01)vs(85.63±24.20)pg/ml]水平与NDR比较,差异均有统计学意义(P0.01)。PDR组血清Lp-PLA2[(180.90±48.71)vs(153.70±40.61)μg/L]、VEGF[(170.34±35.47)vs(146.16±36.01)pg/ml]水平与NPDR组比较,差异有统计学意义(P0.01)。糖尿病病程(β=0.135,P0.05)、HbA1c(β=0.141,P0.01)、LDL-C(β=0.291,P0.05)、TG(β=0.347,P0.05)、VEGF水平(β=0.313,P0.05)和DR程度(β=0.354,P0.05)均与Lp-PLA2水平相关。结论 DR患者血清Lp-PLA2水平升高,与病程、血糖、TG、VEGF水平和DR程度密切相关。
[Abstract]:Objective to observe the level of lipoprotein associated phospholipid A _ 2 (Lp-PLA _ 2) in patients with Dr at different stages and to analyze the related factors.Methods one hundred and sixty patients with T2DM were divided into three groups: non proliferative diabetic retinopathy group, non proliferative diabetic retinopathy group and proliferative diabetic retinopathy group.The levels of Lp-PLA2, Lp-PLA2 and VEGF were measured, and the factors affecting serum Lp-PLA2 were analyzed by multiple linear regression analysis.缁撴灉PDR鍜孨PDR缁勮��娓匧p-PLA2[(180.90卤48.71)vs(153.70卤40.61)vs(127.01卤37.64)渭g/L],VEGF[(170.34卤35.47)vs(146.16卤36.01)vs(85.63卤24.20)pg/ml]姘村钩涓嶯DR姣旇緝,宸�寮傚潎鏈夌粺璁″�︽剰涔，

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