疏肝健脾消瘿汤治疗桥本氏甲状腺炎合并甲减的临床观察

发布时间：2018-04-14 06:21

本文选题：疏肝健脾消瘿汤 + 桥本氏甲状腺炎　；参考：《山东中医药大学》2016年硕士论文

【摘要】：目的:观察疏肝健脾消瘿汤合优甲乐治疗肝郁脾虚型桥本氏甲状腺炎合并甲减的临床疗效,并结合现代医学深入探索中药的作用机制,从而突出中医药的优势。方法:将临床上诊断为桥本氏甲状腺炎合并甲减肝郁脾虚型的60例患者随机分为两组:治疗组(B组)、对照组(A组),B组30例,给予疏肝健脾消瘿汤合优甲乐治疗;A组30例,给予优甲乐治疗,4周为一疗程,连用12周。所有患者治疗前、后测定:(1)甲状腺激素水平及TPOAb、TGAb水平;(2)甲状腺左右叶及峡部厚度;(3)CD4(10)、CD8(10)、CD4(10)/CD8(10)水平;(4)中医证候积分及综合疗效评定;(5)血常规、肝功、肾功等安全性指标。结果:两组治疗前比较,年龄、性别、病程、甲状腺激素水平、TPOAb、TGAb滴度水平、甲状腺左右叶及峡部厚度、CD4(10)、CD8(10)、CD4(10)/CD8(10)水平及中医证候积分等方面无明显差异,P(29)0.05,具有可比性;治疗后比较:两组综合疗效比较,B组总有效率96.7%;A组总有效率83.3%,B组总有效率明显高于A组,P0.05;两组症状积分均较治疗前有所降低,B组疗效优于A组,P0.05;B组在改善甲状腺激素(FT4、TSH)水平,TPOAb、TGAb滴度水平,甲状腺左右叶及峡部厚度,CD4(10)、CD4(10)/CD8(10)水平方面明显优于A组,P0.05;安全性指标较治疗前均未见明显变化。结论:疏肝健脾消瘿汤合优甲乐治疗桥本氏甲状腺炎合并甲减疗效肯定,值得进一步深入探讨。
[Abstract]:Objective: to observe the clinical effect of Shugan Jianpi Xiaoying decoction and Youjia Le in treating Hashimoto's thyroiditis combined with hypothyroidism in the type of liver stagnation and spleen deficiency, and to explore the mechanism of traditional Chinese medicine in order to highlight the advantages of traditional Chinese medicine.Methods: sixty patients with Hashimoto's thyroiditis combined with hypothyroidism liver depression and spleen deficiency were randomly divided into two groups: treatment group B group, control group A group (n = 30) and group A (n = 30) treated with Shugan Jianpi Xiaoying decoction and you Jia Le group (n = 30).A course of treatment was given for 4 weeks and continued for 12 weeks.Before and after treatment, the levels of thyroid hormone and TPOAbTGAb were measured before and after treatment. (2) the thickness of the left and right lobes and isthmus of the thyroid gland was determined.Results: there was no significant difference between the two groups in age, sex, course of disease, thyroid hormone level and TPOAb TGAb titer, the thickness of left and right thyroid lobe and isthmus and the level of CD410 / CD810 / CD810 and the score of TCM syndromes (P290.05).Comparison after treatment: the total effective rate of group B was 96. 7% and the total effective rate of group B was significantly higher than that of group A (83.33%), and the total effective rate of group B was significantly higher than that of group A (P 0. 05%), and the symptom score of group B was lower than that of group B (P 0. 05%) before treatment, and the total effective rate of group B was better than that of group B (group B) in improving thyroid gland.The titer of TPOAbAb TGAb,The thickness of left and right lobe and isthmus of thyroid gland was significantly better than that of group A (P 0.05), and there was no significant change in safety index.Conclusion: the curative effect of Shugan Jianpi Xiaoying decoction combined with Youjia Le in treating Hashimoto's thyroiditis with hypothyroidism is definite and worthy of further discussion.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R581

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