不同民族2型糖尿病患者血清内脏脂肪素的比较分析

发布时间：2018-04-16 06:43

本文选题：2型糖尿病 + 内脏脂肪素　；参考：《青海大学》2017年硕士论文

【摘要】：目的:对不同民族2型糖尿病患者visfatin水平的比较分析,观察不同民族间visfatin的变化。方法:随机选取三代及三代以上未进行异族通婚,在2015年-2016年期间在青海省人民医院门诊健康体检者105例(无慢性心脏疾患;肝肾功能正常;年龄小于82岁,大于25岁)。其中汉族36例,回族36例,藏族33例。同时选取三代及三代以上未进行异族通婚,在2015年-2016年期间在我院内科病房15楼住院的T2DM患者97例(符合目前国际上通用的WHO诊断标准(1999),年龄小于80岁,大于20岁)。其中汉族34例,回族31例,藏族32例。收集各组患者的年龄、性别、身高、体重、病程;然后收集生化及其它指标:SUA、ACR、Hb Alc、LDL-C、TC、HDL-C、TG、FPG、PPG、FINS、Hcy、VD3,并对数据进行统计学分析和处理。结果:1、在同一个民族间,年龄在NG与T2DM组,无统计学意义(P0.05)。2、3个民族间性别所占的构成比,在NG与T2DM组,无统计学意义(P0.05)。3、对照组中:(1)visfatin、SUA、TG、PPG、VD3回族均高于汉族,两者之间有统计学意义;TC、HDL-C汉族高于回族,两者之间有统计学意义。(2)visfatin、TG、PPG、VD藏族高于汉族,两者之间差异有统计学意义。(3)Hb A1c、TG、HDL藏族高于回族,两者之间差异有统计学意义。T2DM组中:(1)visfatin、Hb A1c、TG、Hcy,藏族高于汉族,两组间差异有统计学意义;(2)TG、FPG回族高于汉族,两组间差异有统计学差意义。(3)visfatin、Hb A1c、HDL-C、Hcy藏族高于回族,两组间差异有统计学意义;回族TG水平高于藏族,两组间差异有统计学意义。同一民族间比较:(1)visfatin、SUA、Hb A1c、TC、TG、HDL-C、ACR、Hcy、FPG、PPG、VD3在同一民族汉族间差异有统计学意义。且SUA、Hb A1c、TC、TG、HDL-C、ACR、Hcy、FPG、PPG,T2DM组均高于对照组;visfatin、VD3对照组高于T2DM组。(2)Hb A1c、TG、HDL-C、ACR、LDL-C、Hcy、FPG、PPG、VD3在同一民族回族间差异有统计学意义。且Hb A1c、TG、ACR、LDL-C、Hcy、FPG、PPG、T2DM组均高于对照组;HDL-C、VD3对照组高于T2DM组。(3)visfatin、Hb A1c、TC、TG、HDL-C、ACR、Hcy、FPG、PPG、VD3在同一民族藏族间差异有统计学意义,P0.05。且visfatin、Hb A1c、TC、TG、ACR、Hcy、FPG、PPG,T2DM组高于对照组;HDL-C、VD3对照组高于T2DM组。4、在非肥胖组中:(1)FPG在回族中高于汉族,两者之间有统计学意义;(2)visfatin藏族高于汉族、回族,差异有统计学意义;FPG回族高于藏族,两者之间有统计学意义。在肥胖组中:(1)TG、FPG回族高于汉族,两者之间有统计学意义;(2)visfatin、HDL-C、Hcy藏族高于回族,两者之间有统计学意义;TG回族高于藏族,两者之间有统计学意义;ACR水平藏族均高于汉族、回族,差异有统计学差异。同民族间比较:(1)肥胖组汉族、回族、藏族ACR均高于非肥胖组,差异有统计学意义。结论:在不同民族间2型糖尿病患者中visfatin水平是有差异的,藏族visfatin分别高于回族、汉族;visfatin与T2DM的发病机制有着潜在的联系,我们今后可能为治疗不同民族2型糖尿病患者提供一条新的途径。
[Abstract]:Objective: to compare and analyze the level of visfatin in patients with type 2 diabetes mellitus from different nationalities and to observe the changes of visfatin in different nationalities.Methods: 105 patients (no chronic heart disease, normal liver and kidney function, < 82 years old, more than 25 years old) were selected randomly from the third generation and more than three generations who had no interracial marriage in the outpatient clinic of Qinghai Provincial people's Hospital from 2015 to 2016.There were 36 cases of Han nationality, 36 cases of Hui nationality and 33 cases of Tibetan nationality.At the same time, 97 T2DM patients who were not intermarried for three generations or more and hospitalized on the 15th floor of internal medicine ward in our hospital from 2015 to 2016 were selected (according to the current international WHO diagnostic standard / 1999), the age is less than 80 years old and the age is more than 20 years old.There were 34 cases of Han nationality, 31 cases of Hui nationality and 32 cases of Tibetan nationality.The age, sex, height, weight and course of disease of the patients were collected, and then the biochemical and other indexes were collected and analyzed statistically.Results in the same ethnic group, there was no significant difference between the age of NG and T2DM group, there was no significant difference in the proportion of sex composition among the three ethnic groups, and in NG and T2DM group, there was no significant difference in P0.05. 3. In the control group, the proportion of male and female in the control group was higher than that in the Han nationality.There was statistically significant difference between the Han nationality and the Hui nationality in HDL-C between the two groups, and there was a statistical significance between them. There was a significant difference between the two groups. The difference between them was statistically significant. The difference between them was higher than that of the Hui nationality, and the difference between them was higher than that of the Hui nationality, and the difference between the two groups was higher than that of the Han nationality, and the difference between the two groups was higher than that of the Hui nationality.The difference between the two groups was statistically significant. The difference between the two groups was statistically significant. The difference between the two groups was statistically significant. The difference between the two groups was statistically significant. The difference between the two groups was statistically significant. The difference between the two groups was statistically significant. The difference between the two groups was higher than that of the Hui nationality, and the difference between the two groups was statistically significant.The TG level of Hui nationality was higher than that of Tibetan nationality, and the difference between the two groups was statistically significant.There was a significant difference in HbA1cHbA1cT TGG (HDL-CU), Hcyl, FPG, PPGV, VD3 between the same ethnic group and the Han nationality of the same ethnic group compared with that of the same ethnic group.Moreover, there were significant differences between the two groups in the T2DM group and the control group. The difference was statistically significant between the control group and the control group. The difference was statistically significant between the two groups. The difference was statistically significant between the same ethnic group and the control group (P < 0.05). The difference was statistically significant between the control group and the control group (P < 0.05). The difference was statistically significant between the two groups in the same ethnic group. The difference was statistically significant between the control group and the control group (P < 0.05). The difference was statistically significant between the control group and the control group, which was higher than that in the control group and the control group was higher than that in the T2DM group.In addition, the levels of HDL-CnVD3 in T2DM group were higher than those in T2DM group. There was a significant difference between the two groups (P55.The difference was significant between the same ethnic group and the same ethnic group (P < 0.05). The results showed that there was no significant difference between the two groups in HbA1cA1C, HcyFPGPPGVD3 and HDL-C1C T2DM group, and there was a significant difference between the two groups in the same ethnic group (P55.The difference between the two groups was significant (P < 0.05), and the difference was significant (P < 0.05). The difference was significant (P < 0.05) between the two groups.Moreover, visfatinine HbA1c TCG, HcyFPGG, PPGN T2DM group was higher than control group HDL-CnVD3 control group was higher than T2DM group .4, in non-obese group, the FPG was higher in Hui nationality than that in Han nationality, there was statistical significance between them, there was significant difference between them, and the difference was statistically significant (P < 0.05), and the difference was statistically significant (P < 0.05), and the difference between them was higher than that of Han nationality (P < 0.05), and the difference was statistically significant (P < 0.05) between the control group and the control group (P < 0.05).There is statistical significance between the two.In the obese group, the FPG level of the FPG was higher than that of the Han nationality, and there was statistical significance between the two groups. The Hcy of Hcy in HDL-Cy was higher than that of the Hui, and there was statistical significance between the two groups. The ACR level of the Hui nationality was higher than that of the Han nationality, and the level of ACR between the two groups was higher than that of the Han nationality and Hui nationality.The difference is statistically significant.The ACR of Han, Hui and Tibetan in obese group was higher than that in non-obese group, and the difference was statistically significant.Conclusion: there are differences in the level of visfatin among different nationalities in type 2 diabetes mellitus. The level of visfatin in Tibetan nationality is higher than that in Hui nationality. There is a potential association between visfatin and the pathogenesis of T2DM in Han nationality.We may provide a new approach to the treatment of type 2 diabetes in different nationalities.
【学位授予单位】：青海大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R587.1

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