女性年龄相关的股骨颈几何参数参考值

发布时间：2018-04-16 12:16

本文选题：女性人群 + 骨密度　；参考：《中国骨质疏松杂志》2017年06期

【摘要】：目的调查女性人群年龄相关的股骨颈几何参数(FNGPs)和建立FNGPs参考数据库。方法女性健康志愿者5478名(年龄10~91岁),采用DXA骨密度仪测量受试者FNGPs,包括股骨颈外周直径(OD)、横截面积(CSA)、皮质厚度(CT)、内皮质直径(ED)、抗曲比率(BR)、截面系数(SM)、截面转动惯量(CSMI)和抗压强度指数(CSI),并分析其随年龄的变化关系。结果各种FNGPs随年龄的分布趋势均采用三次回归模型拟合优度最佳,拟合曲线方程的决定系数均有显著性意义(R2=0.047~0.344,均P=0.000),但它们的散点分布趋势随指标而不同,其中CSA、CT、SM、CSMI和CSI在35岁之前随年龄而增加,之后随年龄增加而逐渐下降;只有BR约在40岁之后则随年龄而快速增加。调整年龄之后,身高、体重和BMI与股骨颈OD、CSA、CT、ED、SM和CSMI呈显著正相关关系(r=0.043~0.546,均P=0.002~0.000),BR和CSI则与身高、体重和BMI呈负相关关系(r=-0.057至-0.387,均P=0.000)。结论本研究建立的女性人群FNGPs参考数据库,将为临床评价和预测女性股骨颈骨质疏松性骨折风险提供可靠的参考值。
[Abstract]:Objective to investigate the age-related femoral neck geometric parameters of female population and establish FNGPs reference database.Methods 5478 healthy female volunteers (10 ~ 91 years old) were measured by DXA absorptiometry, including femoral neck circumference, cross sectional area, cortical thickness, cortical diameter, internal cortical diameter, anti-curvature ratio, cross section coefficient and cross section rotation.The moment of inertia (CSMI) and the compressive strength index (CSI) are analyzed and their relationship with age is analyzed.Results the distribution trend of FNGPs with age was the best with cubic regression model, and the determining coefficient of fitting curve equation was significant (P < 0. 047), P < 0. 0000.000, but the distribution trend of scattered point was different with the index.CSMI and CSI increased with age before 35 years old, then decreased gradually with age, but Br increased rapidly with age after 40 years old.After adjusting for age, there was a significant positive correlation between height, weight and BMI and CSMI. There was a significant positive correlation between SM and CSMI. There was a negative correlation between height, weight and BMI, and there was a negative correlation between height, weight and BMI (P 0.000).Conclusion the FNGPs reference database of female population established in this study will provide a reliable reference value for clinical evaluation and prediction of female femoral neck osteoporotic fracture risk.
【作者单位】：中南大学湘雅二医院代谢内分泌研究所国家代谢性疾病临床研究中心;湖南省湘乡市第二人民医院内分泌科;山东省菏泽市中医院;
【基金】：国家自然科学基金项目(81500685)
【分类号】：R580;R683

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