度洛西汀治疗糖尿病周围神经病变性疼痛的疗效

发布时间：2018-04-18 01:21

本文选题：度洛西汀 + 糖尿病神经病变性疼痛　；参考：《中国老年学杂志》2017年01期

【摘要】：目的探讨度洛西汀治疗糖尿病周围神经病变性疼痛(DPNP)的有效性及安全性。方法 31例DPNP患者随机分为度洛西汀组和安慰剂组,分别给予度洛西汀、安慰剂维持治疗12 w。治疗前及治疗过程中随访所有研究对象24 h平均疼痛程度评分,24 h最大疼痛程度评分及夜间平均疼痛程度评分,并且通过简明疼痛量表(BPI-S、BPI-I)、Mc Gill疼痛问卷简表-感觉部分(SF-MPQ)等评估研究对象的病情变化。检测外周血糖脂代谢等基础生化指标,同时记录随访过程中不良反应的发生。结果治疗前,两组患者主要与次要疗效指标相比较无明显差异(P0.05)。治疗12 w后,与安慰剂组相比较,度洛西汀组24 h平均疼痛程度评分〔(4.46±1.13)分vs(2.38±1.39)分〕、24 h最大疼痛程度评分〔(5.69±1.49)分vs(4.00±1.64)分〕及其他指标评分均显著下降(P0.05),其次,度洛西汀组生活质量明显得到改善(P0.05)。两组患者肝肾功、糖化血红蛋白和血脂治疗前后变化无明显差异。整个治疗过程两组患者均无自杀倾向及抑郁症的发生。结论度洛西汀能够明显改善DPNP患者的疼痛严重程度及生活质量,且安全性良好。
[Abstract]:Objective to investigate the efficacy and safety of doloxetine in the treatment of diabetic peripheral neuropathic pain.Methods Thirty-one patients with DPNP were randomly divided into two groups: doloxetine group and placebo group.All the subjects were followed up before and during the course of treatment for 24 h mean pain degree score, 24 h maximum pain degree score and night average pain degree score.The changes of the patients' condition were evaluated by the brief pain scale (BPI-SPI-BPI-I) and the Mc Gill pain questionnaire (SF-MPQQ).Peripheral blood glucose and lipid metabolism and other basic biochemical indicators were detected, and adverse reactions were recorded during follow-up.Results before treatment, there was no significant difference between the two groups.After 12 weeks of treatment, compared with the placebo group, the average pain degree score of doxetine group was 4.46 卤1.13 (vs(2.38 卤1.39) and the maximum pain degree at 24 h (5.69 卤1.49) vs(4.00 卤1.64).The quality of life of Doxetine group was significantly improved (P 0.05).There was no significant difference between the two groups in liver and kidney function, glycosylated hemoglobin and blood lipids before and after treatment.There was no suicidal tendency and depression in both groups.Conclusion Doxetine can significantly improve the severity of pain and quality of life in patients with DPNP, and the safety is good.
【作者单位】：重庆医科大学附属永川医院内分泌科;重庆医科大学附属第二医院内分泌科;
【基金】：重庆市卫生局医学科研计划项目(No.2011-2-286;2012-2-155)
【分类号】：R587.2

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