HAND发病机制及其相关生物标志物研究进展

发布时间：2018-04-18 08:13

本文选题：艾滋病病毒 + 艾滋病病毒相关神经认知障碍　；参考：《中国艾滋病性病》2017年09期

【摘要】：由于艾滋病病毒(HIV)的噬神经性,HIV侵入中枢神经系统可导致神经认知损伤。随着联合抗反转录病毒疗法(ART)的广泛使用,HIV相关神经认知障碍(HAND)的严重阶段HIV相关性痴呆患者显著减少,但轻型HAND的发病率确有升高趋势。现行的HAND诊断标准是基于临床评估、神经心理学测试和自我报告日常活动进行的诊断,难以准确地对HAND诊断和分类,亟待依据HAND发病机理探索敏感的、有效的生物标志物用于预测HAND的发生风险,辅助HAND的临床诊断及疗效评估。现将HAND发病机制研究最新进展及其相关生物标志物的探索进展进行综述。
[Abstract]:The invasion of HIV into the central nervous system by HIV / AIDS can lead to neurocognitive impairment.With the extensive use of antiretrovirals combined with ART, the incidence of HIV associated dementia in severe stage of HIV related dementia decreased significantly, but the incidence of mild HAND did increase.The current diagnostic criteria for HAND are based on clinical evaluation, neuropsychological tests and self-reported daily activities, so it is difficult to diagnose and classify HAND accurately. Therefore, it is urgent to explore the sensitivity based on the pathogenesis of HAND.Effective biomarkers are used to predict the risk of HAND and to assist in the clinical diagnosis and evaluation of the efficacy of HAND.This paper reviews the recent progress in the pathogenesis of HAND and its biomarkers.
【作者单位】：首都医科大学附属北京佑安医院;
【基金】：国家自然科学基金面上项目:基于多模态磁共振的HIV相关神经认知障碍综合征无症状神经认知损伤生物标志物研究(81571634)~~
【分类号】：R512.91

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