外泌体的免疫调节作用及在自身免疫性疾病中的研究

发布时间：2018-04-21 03:13

本文选题：自身免疫性疾病 + 免疫调节作用　；参考：《中国免疫学杂志》2017年12期

【摘要】：正1外泌体的概述外泌体(Exosomes)是直径大约在30~100 nm之间的双层脂质膜囊泡,可由不同类型的细胞脱落释放,存在于多种体液中,包括血液、尿液、支气管肺泡灌洗液,甚至在唾液和乳汁中也可发现外泌体。与它的起源细胞相比,外泌体含有丰富的胆固醇、神经酰胺、鞘磷脂等脂类成分,这些成分使得外泌体的结构更加稳定~([1])。外泌体包括丰富的蛋白质,如:黏附分子、膜转运因子、趋化因子、信号转导因子、细胞骨架蛋白、热休克蛋白、蛋白酶和细胞特异性抗原
[Abstract]:Exocrine exocrine exosomes (exosomeses) are bilayer lipid membrane vesicles about 30 ~ 100 nm in diameter, which can be released by different types of cells and are present in a variety of body fluids, including blood, urine, bronchoalveolar lavage fluid, or bronchoalveolar lavage fluid. Exocrine bodies can be found even in saliva and milk. Compared with its origin cells, exocrine contains rich lipid components such as cholesterol, ceramide and sphingomyelin, which make the structure of exocrine more stable ([1]). Exosomes include a wealth of proteins such as adhesion molecules, membrane transporters, chemokines, signal transduction factors, cytoskeletal proteins, heat shock proteins, proteases, and cell-specific antigens
【作者单位】：中国医科大学附属第一医院内分泌与代谢病科;
【基金】：国家自然科学基金面上项目(81471003、81770784)资助
【分类号】：R593.2

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