葛根芩连汤联合硫辛酸治疗老年糖尿病周围神经病变临床疗效评价

发布时间：2018-04-21 04:57

本文选题：葛根芩连汤 + 硫辛酸　；参考：《中华中医药学刊》2017年09期

【摘要】：目的:旨在评价葛根芩连汤联合α-硫辛酸治疗糖尿病周围神经性病变(DPN)的临床疗效和安全性。方法:DPN患者90例,随机分为常规组和治疗组,每组各45例,常规组给予0.9%氯化钠注射液200 m L(5m L 10%氯化钾+5 m L 25%硫酸镁+40 mg三磷酸腺苷+100U辅酶A+维生素B1 150 mg+维生素B12 0.5mg),另补加α-硫辛酸注射液600 mg+生理盐水200 m L静脉滴注,1次/d,进行两个疗程,每个疗程持续15 d,期间间隔停药3 d。治疗组在此基础上加用葛根芩连汤,疗程同常规组。观察各组患者的临床症状、体征、评价治疗前后治疗有效率,神经传导速度以及不良反应等。结果:治疗组总体有效率为95.56%,明显优于常规组66.67%,且神经传导速度明显提高,差异均有显著学意义(P0.05),两组均无不良反应发生。结论:硫辛酸治疗治疗糖尿病周围神经性病变疗效显著,值得临床推广。
[Abstract]:Objective: to evaluate the efficacy and safety of Gegen Qinlian decoction combined with 伪-lipoic acid in the treatment of diabetic peripheral neuropathy. Methods 90 patients with DPN were randomly divided into routine group and treatment group with 45 cases in each group. The routine group was given 0.9% sodium chloride injection 200 mL / L 5 m L 10% potassium chloride 5 mL 5% magnesium sulfate 40 mg adenosine triphosphate 100U coenzyme A vitamin B 1 150 mg vitamin B 12 0.5 mg / g and 伪 -lipoic acid injection 600 mg normal saline 200 m. L-intravenous drip was given once a day for two courses of treatment. Each course of treatment lasted for 15 days and stopped at intervals of 3 days. On this basis, the treatment group was treated with Gegen Qinlian decoction for the same course of treatment as the routine group. The clinical symptoms and signs were observed, and the effective rate, nerve conduction velocity and adverse reactions were evaluated before and after treatment. Results: the total effective rate of the treatment group was 95.56, which was significantly better than that of the routine group (66.67), and the nerve conduction velocity was significantly increased (P 0.05). There was no adverse reaction in both groups. Conclusion: the therapeutic effect of lipoic acid on diabetic peripheral neuropathy is remarkable and worth popularizing.
【作者单位】：北京中医药大学枣庄医院;青岛市胸科医院;
【基金】：青岛市中医科研计划项目(2014-zyz002)
【分类号】：R587.2

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