类风湿关节炎患者X线片表现与患者Treg细胞含量及血清炎性因子水平的关系

发布时间：2018-04-21 07:26

本文选题：关节炎 + 类风湿　；参考：《重庆医学》2017年21期

【摘要】：目的探讨类风湿关节炎(RA)患者血清调节性T淋巴细胞(Treg)及炎性因子水平与患者X线片表现及病情的关系。方法选取2015年6月至2016年6月在该院治疗的70例RA患者作为RA组,以20例体检健康者为对照组,检测其血清Treg、肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-6、IL-8水平,分析Treg及各项炎性因子水平与患者关节X线片表现及关节功能的关系。结果 RA组患者Treg水平为(4.32±1.39)×106/L明显低于对照组的(7.57±2.37)×106/L,TNF-α、IL-6、IL-8水平分别为(23.63±5.36)ng/mL、(8.64±6.74)pg/mL、(7.63±5.56)pg/mL明显高于对照组的(6.54±1.53)ng/mL、(2.37±1.39)pg/mL、(2.36±1.17)pg/mL,差异均有统计学意义(P0.05);骨损伤或关节损伤程度越重,血清TNF-α、IL-6、IL-8水平越高,Treg水平越低;logistic回归分析提示年龄、TNF-α水平上升、Treg水平下降是RA患者出现骨损伤的独立危险因素。结论RA患者Treg和炎性因子水平与骨损伤密切相关。
[Abstract]:Objective to investigate the relationship between the level of serum regulatory T lymphocyte (Treg) and inflammatory factors in patients with rheumatoid arthritis (RA) and the manifestation of X-ray film and the condition of the patients. Methods 70 RA patients treated in the hospital from June 2015 to June 2016 were selected as RA group, and 20 healthy persons were selected as the group, and the serum Treg, tumor necrosis factor - alpha (TNF-) was detected. Alpha), interleukin (IL) -6, IL-8 level, analysis of the relationship between Treg and the levels of inflammatory factors and joint function of the patients. Results the Treg level in group RA was (4.32 + 1.39) x 106/L significantly lower than that of the control group (7.57 + 2.37) x 106/L, TNF- alpha, IL-6, IL-8 (23.63 + 5.36) ng/mL, (8.64 + 6.74), respectively, (7.63 + 5.5) 6) pg/mL was significantly higher than that of the control group (6.54 + 1.53) ng/mL, (2.37 + 1.39) pg/mL, (2.36 + 1.17) pg/mL, and the difference was statistically significant (P0.05). The higher the degree of bone injury or joint injury, the higher the level of serum TNF- a, IL-6, IL-8, the lower the level of Treg; logistic regression analysis suggested that age, TNF- alpha level rose and Treg level decreased is the bone of the patient. Conclusion the levels of Treg and inflammatory factors in RA patients are closely related to bone injury.

【作者单位】：首都医科大学附属北京潞河医院综合科;
【分类号】：R593.22

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