生命早期饥荒暴露对成年期代谢综合征患病风险的影响

发布时间：2018-04-21 09:34

本文选题：营养不良 + 胎儿　；参考：《中华疾病控制杂志》2017年07期

【摘要】：目的探索生命早期饥荒暴露对成年后代谢综合征患病风险的影响。方法采用中国健康与养老追踪调查2011年全国基线数据,共2 854名研究对象纳入分析。将出生于1956-1958年、1959-1961年和1962-1964年的研究对象分为饥荒前出生组、饥荒期出生组以及非暴露组(对照组)。以中华医学会糖尿病学分会2004年相关标准诊断代谢综合征。联合应用双重差分模型和疾病风险评分匹配方法控制偏倚和混杂。结果饥荒前出生组、饥荒期出生组、非暴露组代谢综合征患病率分别为16.00%、16.47%和14.86%,无论是否进行疾病风险评分匹配,模型中双重差分项均不显著(均有P0.05),饥荒暴露组与非暴露组相比,代谢综合征患病风险无显著差异。结论本研究结果提供的证据不足以充分证实生命早期饥荒暴露会增加成年后代谢综合征患病风险,有待大样本人群研究对该问题作进一步探索。
[Abstract]:Objective to explore the effect of early life famine exposure on the risk of metabolic syndrome in adults. Methods A total of 2 854 subjects were included in the national baseline data of China Health and Old-age Survey in 2011. Subjects born from 1956-1958 to 1959-1961 and 1962-1964 were divided into pre-famine birth group, famine birth group and non-exposed group (control group). Metabolic syndrome was diagnosed according to the relevant criteria of Diabetes Society of Chinese Medical Association in 2004. Double differential model and disease risk score matching were used to control bias and confounding. Results the prevalence of metabolic syndrome in pre-famine birth group, famine birth group and non-exposed group were 16.00% and 14.86% respectively, regardless of whether the disease risk score was matched or not. There was no significant difference between the two groups (P 0.05), and there was no significant difference in the risk of metabolic syndrome between the famine exposed group and the non-exposed group. Conclusion the evidence provided by this study is not sufficient to prove that early life famine exposure can increase the risk of adult metabolic syndrome.
【作者单位】：北京大学公共卫生学院流行病与卫生统计学系;
【基金】：国家自然科学基金(81473067)
【分类号】：R589

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