一氧化碳中毒迟发性脑病患者应用银杏叶提取物治疗前后神经功能的变化

发布时间：2018-04-22 03:34

本文选题：急性一氧化碳中毒 + 迟发性脑病　；参考：《实用医学杂志》2017年10期

【摘要】：目的:观察银杏叶提取物对急性一氧化碳中毒迟发性脑病(DEACMP)神经功能的影响。方法:选择我院2012年4月至2017年2月DEACMP患者96例,随机分成对照组和治疗组。对照组给予高压氧、降低颅内压及促进脑细胞代谢等治疗;治疗组在常规治疗基础上静脉滴注银杏叶提取物70 mg(加入0.9%氯化钠注射液250 mL中),每日1次,连续应用2周。DEACMP患者于入院24 h内及治疗后14 d检查头颅磁共振(MRI)成像和脑电图(EEG),观察患者MRI和EEG的变化,同时观察两组患者简易精神状态检查量表(MMSE)、Barthel指数(BI)、蒙特利尔认知评估量表(Mo CA)变化及临床疗效。结果:治疗组总有效39例(总有效率81.25%)高于对照组总有效29例(总有效率60.42%),差异有统计学意义(χ~2=5.042,P=0.025);两组患者入院时头颅MRI异常信号、EEG异常率及MMSE、BI及Mo CA评分比较差异无统计学意义(P0.05);治疗组患者治疗后14 d MRI异常信号、EEG异常率及MMSE、BI及Mo CA评分改善优于对照组,两组比较差异有显著性(P0.05)。DEACMP患者MMSE评分与患者病情程度呈负相关(r=-0.832,P=0.000)。结论:银杏叶提取物治疗能使DEACMP患者MRI病灶范围和EEG异常率及MMSE、BI及Mo-CA评分改善,有一定的临床治疗效果。
[Abstract]:Aim: to observe the effect of ginkgo biloba extract on nerve function of DEACMP in acute carbon monoxide poisoning. Methods: 96 patients with DEACMP from April 2012 to February 2017 were randomly divided into control group and treatment group. The control group was treated with hyperbaric oxygen, reducing intracranial pressure and promoting brain cell metabolism, and the treatment group was treated with 70 mg Ginkgo biloba extract (added 0.9% sodium chloride injection 250 mL, once a day) on the basis of routine treatment, and the treatment group was treated with Ginkgo biloba extract 70 mg by intravenous drip on the basis of routine treatment. The MRI and EEG were observed in patients with DEACMP after 2 weeks of continuous application. The patients were examined with cranial magnetic resonance imaging (MRI) and electroencephalogram (EEG) within 24 hours of admission and 14 days after treatment. At the same time, the changes of MMSE Barthel Index and Montreal Cognitive Assessment scale (MMSE) and the clinical efficacy were observed in the two groups. Results: the total effective rate of 39 cases (total effective rate 81.25%) in the treatment group was higher than that in the control group (60.42%) (the total effective rate was 60.42%), the difference was statistically significant (蠂 ~ 2 + 5.042), the abnormal rate of abnormal MRI signals and the scores of MRI and Mo on admission were poor in the two groups. The abnormal rate of MRI signal and the scores of MMSE BI and Mo CA in the treatment group were better than those in the control group 14 days after treatment. The difference between the two groups was significant (P 0.05). The MMSE score of DEACMP patients was negatively correlated with the severity of the disease. Conclusion: ginkgo biloba extract can improve the focus range of MRI, the abnormal rate of EEG and the scores of MMSE BI and Mo-CA in patients with DEACMP.
【作者单位】：河北医科大学哈励逊国际和平医院急救医学部;河北医科大学哈励逊国际和平医院急诊综合病房;河北医科大学哈励逊国际和平医院EICU;
【基金】：河北省省级科技计划项目(编号:1627771019D)
【分类号】：R595.1;R747.9

【相似文献】