荟萃分析灯盏花素联合甲钴胺治疗糖尿病周围神经病变的安全性与有效性

发布时间：2018-04-23 20:40

本文选题：Meta分析 + 灯盏花素　；参考：《中成药》2016年05期

【摘要】：目的系统分析灯盏花素联合甲钴胺治疗糖尿病周围神经病变的安全性与有效性。方法依据PICOS[patient(患者),intervention(干预),comparison(对比),outcome(结果),study(研究类型)]原则,通过电子检索和人工检索综合检索公开发表及未公开发表的中文或英文相关灯盏花素联合甲钴胺治疗糖尿病周围神经病变的随机对照试验文献。检索年限均1990至2015年8月。按照纳入标准和排除标准筛选文献,提取资料和进行质量评价后,使用采用Rev Man 5.2软件进行分析。结果纳入18个随机对照试验,Meta分析结果显示灯盏花素联合甲钴胺治疗组总体有效率及改善神经感觉和运动传导速度上均优于对照组,并具有良好的安全性。结论灯盏花素联合甲钴胺作为糖尿病周围神经病变的临床治疗的选择,优于单用甲钴胺及丹参注射液联合维生素B12及B1的治疗并且有着良好的安全性。
[Abstract]:Objective to analyze the safety and efficacy of breviscapine combined with mecobalamin in the treatment of diabetic peripheral neuropathy. Methods according to the principle of PICOS, A randomized controlled trial of Chinese or English related breviscapine combined with mecobalamin in the treatment of diabetic peripheral neuropathy was searched by electronic search and artificial retrieval. The search time was 1990 to August 2015. The literature was screened according to the inclusion criteria and exclusion criteria, the data were extracted and the quality was evaluated, and the analysis was carried out by using Rev Man 5.2 software. Results Meta-analysis of 18 randomized controlled trials showed that the overall effective rate of breviscapine combined with mecobalamin was better than that of the control group in improving nerve sensory and motor conduction velocities and had good safety. Conclusion Breviscapine combined with mecobalamin is superior to methylcobalamin and salvia miltiorrhiza injection combined with vitamin B12 and B1 in the treatment of diabetic peripheral neuropathy.
【作者单位】：安徽中医药大学研究生院;安徽中医药大学第一附属医院内分泌科安徽省中医药科学院;
【基金】：中医药部门公共卫生服务补助资金中医药标准制修订项目(SATCM-2015-BZ098) 国家自然科学基金(81573944) 国家中医药管理局国家基本公共卫生服务项目(20131012)
【分类号】：R587.2

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