艾塞那肽对高海拔地区2型糖尿病伴多囊卵巢综合征患者治疗作用的观察

发布时间：2018-04-25 06:17

本文选题：艾塞那肽 + 高海拔　；参考：《中国糖尿病杂志》2017年03期

【摘要】：目的观察艾塞那肽对高海拔地区T2DM伴多囊卵巢综合征(PCOS)患者的疗效和安全性。方法选取于我科住院的来自高海拔地区T2DM伴PCOS患者75例,随机分为对照(Con)组和艾塞那肽组,Con组口服二甲双胍500mg,3次/d,艾塞那肽组予艾塞那肽5μg,早、晚餐前1h皮下注射,治疗1个月后改为10μg,早、晚餐前1h皮下注射,治疗3个月。测定治疗前后FPG、FIns、2hPG、2hIns、HbA_1c、体重、血脂、性激素等,计算BMI及胰岛素抵抗指数(HOMA-IR)。记录用药期间低血糖发生情况和其他不良反应。结果治疗后两组BMI、HbA_1c、FPG、2hPG、TG、TC、LDL-C、FIns和HOMA-IR较治疗前降低,且艾塞那肽组低于Con组(P0.05)。治疗后两组血清促黄体生成素(LH)及睾酮(T)较治疗前降低(P0.05)。均无低血糖及严重不良反应发生。结论艾塞那肽能有效控制高原地区T2DM伴PCOS患者血糖,降低BMI、改善血脂水平、IR和高雄激素血症。
[Abstract]:Objective to observe the efficacy and safety of isenapeptide in T2DM patients with polycystic ovary syndrome (PCOS) at high altitude. Methods Seventy-five T2DM patients with PCOS from high altitude in our department were randomly divided into two groups: the control group and the control group. The control group and the control group were randomly divided into two groups: the control group and the control group. The control group and the control group were randomly divided into two groups: the control group and the control group. The control group and the control group were randomly divided into two groups: the control group and the control group were given metformin 500 mg of metformin for 3 times per day. After 1 month treatment, it was changed to 10 渭 g, early, 1 hour before dinner, subcutaneously, treated for 3 months. Before and after treatment, 1c, body weight, blood lipids, sex hormones and so on were measured. BMI and insulin resistance index (HOMA-IRN) were calculated. Hypoglycemia and other adverse reactions were recorded during medication. Results after treatment, the two groups of BMI-HbA1cFPGN 2hPGN TGN LDL-CnFIns and HOMA-IR were lower than those of Con group (P 0.05). After treatment, the levels of serum luteinizing hormone (LH) and testosterone (T) in the two groups were lower than those before treatment. No hypoglycemia and severe adverse reactions occurred. Conclusion Isenapeptide can effectively control the blood glucose of T2DM patients with PCOS, decrease BMIs, and improve serum lipids level and hyperandrogenemia.
【作者单位】：青海省人民医院糖尿病科;兰州大学第一临床医学院检验科;
【基金】：吴阶平医学基金(320-6750-15199)
【分类号】：R587.1;R711.75

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