狼疮性肾炎患者伴有甲状腺功能减退症发病的影响因素研究

发布时间：2018-04-27 04:12

本文选题：狼疮性肾炎 + 甲状腺功能减退症　；参考：《青岛大学》2017年硕士论文

【摘要】：目的探讨狼疮性肾炎(Lupus nephritis LN)患者伴有甲状腺功能减退症(Sup clinical hypothyroidism SCH)发病的影响因素。方法选取2013年4月-2017年2月于青岛大学医学院附属医院收治的LN合并SCH患者67例作为观察组,对照组选择同时期入院的单纯LN患者75例。回顾性分析统计患者相关资料,包括性别、年龄、原发病诊断、伴随疾病及高血压、糖尿病等既往史、家族史等基本资料,血液学检查包括:空腹血糖(FBG)、总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、血肌酐(SCr)、尿素氮(BUN)、C反应蛋白(CRP)、24h尿蛋白定量及血清白蛋白。结果观察组和对照组在TG、TC、SCr、BUN、24h尿蛋白定量和血清白蛋白水平差异均有显著性(P0.05),其他指标两组间差异无显著性(P0.05)。Logistic回归分析显示,TG、TC、SCr、BUN、24h尿蛋白定量和血清白蛋白水平为LN患者SCH发病的相关危险因素(P0.05)。结论TG、TC、SCr、BUN、24h尿蛋白量和血清白蛋白水平为LN患者SCH发病的相关危险因素,应当密切监测以上指标,为预防SCH的发生和进展提供重要观测指标。
[Abstract]:Objective to investigate the risk factors of lupus nephritis hypothyroidism (Sch) associated with hypothyroidism. Methods from April 2013 to February 2017, 67 patients with LN combined with SCH were selected as observation group, and 75 patients in control group who were admitted to hospital of Qingdao University Medical College from April 2013 to February 2017. Retrospective analysis of relevant data of patients, including sex, age, diagnosis of primary diseases, associated diseases, hypertension, diabetes mellitus and other basic data, family history, etc. Hematologic examination included fasting blood glucose FBGN, total cholesterol TCU, triglyceride TGG, high density lipoprotein (HDLN), low density lipoprotein (LDLN), serum creatinine (SCR), urea nitrogen bun (BUNC) C-reactive protein, 24 hours urine protein and serum albumin (SA). Results there were significant differences in 24 hours urinary protein quantity and serum albumin level between the observation group and the control group, but there was no significant difference between the other two groups in 24 hours urine protein quantity and serum albumin level. Logistic regression analysis showed that the 24 hours urinary protein quantity and serum albumin level of TGG TCnb were LN patients. The risk factors related to the onset of SCH were P0.05. Conclusion 24 hours urinary protein content and serum albumin level are the risk factors of SCH in LN patients. The above indexes should be closely monitored to provide an important index for preventing the occurrence and progress of SCH.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R593.242;R581.2

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