中性粒细胞与淋巴细胞比值与2型糖尿病肾脏病早期的相关性研究

发布时间：2018-04-30 20:17

本文选题：2型糖尿病 + 糖尿病肾脏病　；参考：《福建中医药大学》2016年硕士论文

【摘要】：目的：探讨外周血中性粒细胞与淋巴细胞比值在2型糖尿病肾脏病早期诊断中的价值。方法：选取2型糖尿病肾脏病早期患者91例,其中男性53例,女性38例。按Mogensen分期法,将91例患者分为两组：糖尿病肾脏病Ⅰ、Ⅱ期为A组(正常白蛋白尿组)36例,其中男性19例,女性17例；糖尿病肾脏病Ⅲ期为B组(微量白蛋白尿组)55例,其中男性34例,女性21例。选取我院体检中心健康体检者63例为C组(健康对照组),其中男性31例,女性32例。对临床资料进行回顾性分析,包括中性粒细胞与淋巴细胞比值、白细胞计数、中性粒细胞计数、淋巴细胞计数、单核细胞计数、C反应蛋白、血脂谱、血糖、24小时尿微量白蛋白及身高、体重、血压、吸烟史等一般情况,了解不同组上述检验结果情况,探讨中性粒细胞与淋巴细胞比值与2型糖尿病肾脏病早期的相关性。采用Logistic回归分析糖尿病肾脏病早期的影响因素。结果：(1).A组、B组的中性粒细胞与淋巴细胞比值、白细胞计数、中性粒细胞计数、单核细胞计数、C反应蛋白水平高于C组,差异有显著统计学意义(P0.01)；(2).A组与B组比较,B组的C反应蛋白水平高于A组,差异有统计学意义(P0.05)；两组的中性粒细胞与淋巴细胞比值、白细胞计数、中性粒细胞计数、单核细胞计数水平差异无统计学意义(P0.05)；(3).三组的淋巴细胞计数水平差异无统计学意义(P0.05)；(4).Logistic回归分析表明,中性粒细胞与淋巴细胞比值、C反应蛋白、甘油三酯、脂蛋白α水平升高是2型糖尿病肾脏病早期的独立影响因素；绘制中性粒细胞与淋巴细胞比值、C反应蛋白等的ROC曲线并计算线下面积。经计算当NLR切值取1.990时,其诊断糖尿病肾脏病效率最高,敏感性为48.4%,特异性为90.5%。结论：中性粒细胞与淋巴细胞比值水平升高是糖尿病肾脏病早期的危险因素,可以预测糖尿病肾脏病早期的发生。
[Abstract]:Objective: to investigate the value of the ratio of peripheral blood neutrophils and lymphocytes in the early diagnosis of type 2 diabetes mellitus. Methods: 91 patients with early type 2 diabetes mellitus were selected, including 53 males and 38 females. According to Mogensen staging, 91 patients were divided into two groups: group A (36 cases of normal albuminuria, 19 males and 17 females) and group B (55 patients with microalbuminuria). There were 34 males and 21 females. A total of 63 cases were selected as group C (31 males and 32 females). The clinical data were analyzed retrospectively, including neutrophil to lymphocyte ratio, leukocyte count, neutrophil count, lymphocyte count, monocyte count, C-reactive protein, blood lipids. Urinary microalbuminuria, height, weight, blood pressure, smoking history, etc., in order to investigate the relationship between neutrophilic granulocyte / lymphocyte ratio and early stage of type 2 diabetes mellitus kidney disease. Logistic regression analysis was used to analyze the factors affecting the early stage of diabetic kidney disease. Results the ratio of neutrophils to lymphocytes, leukocyte count, neutrophil count and monocyte count in group A were higher than those in group C. The level of C-reactive protein in group B was higher than that in group A (P 0.05), and the ratio of neutrophil to lymphocyte, white blood cell count, neutrophil count, and neutrophil count in group A were significantly higher than those in group B (P 0.05). There was no significant difference in monocyte count level (P 0.05). There was no significant difference in lymphocyte count among the three groups. Logistic regression analysis showed that the increase of the ratio of neutrophils to lymphocytes in C-reactive protein, triglyceride and lipoprotein 伪 was an independent influencing factor in the early stage of type 2 diabetes mellitus. The ROC curves of the ratio of neutrophil to lymphocyte and C-reactive protein were plotted and the area under line was calculated. When the value of NLR was 1.990, the efficiency of diagnosis of diabetic kidney disease was the highest, the sensitivity was 48.4 and the specificity was 90.5. Conclusion: the increase of neutrophil / lymphocyte ratio is a risk factor for early diabetic kidney disease and can be used to predict the early stage of diabetic kidney disease.
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R587.2;R692.9

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