类风湿关节炎甲状腺功能状况分析

发布时间：2018-05-01 23:30

本文选题：关节炎 + 类风湿　；参考：《重庆医学》2017年03期

【摘要】：目的研究类风湿关节炎(RA)患者伴发甲状腺功能异常的情况及临床意义。方法采用病例对照研究,纳入200例RA患者为RA组,100例健康体检者为对照组。检测甲状腺功能、抗甲状腺抗体、免疫学指标、常规实验室检查项目,评估RA疾病活动度(DAS28评分)。对RA患者甲状腺功能状况进行分析。比较两组甲状腺功能及抗甲状腺抗体的差异。对甲状腺功能正常与异常RA患者的自身抗体、常规实验室检查项目、DAS28评分进行组间比较和相关性分析。结果 RA组甲状腺功能异常30例(15%),高于对照组7例(7%),两组差异有统计学意义(P0.05)。其中甲状腺功能减低10例,亚临床型甲减6例,低T3/T4综合征9例,甲状腺功能亢进3例,亚临床型甲状腺功能亢进2例。RA组游离三碘甲状腺原氨酸降低,促甲状腺素、抗甲状腺球蛋白抗体和抗甲状腺过氧化物酶抗体增高,较对照组差异有统计学意义(P0.05)。RA组甲状腺功能异常与血红蛋白浓度(HGB)、胆固醇(TC)有相关性。结论 RA患者易出现甲状腺功能异常,以甲状腺功能减低最常见。RA伴发甲状腺功能异常与HGB、TC有相关性。
[Abstract]:Objective to study the clinical significance of thyroid dysfunction in patients with rheumatoid arthritis (RA). Methods A case-control study was conducted in which 200 RA patients were included as RA group and 100 healthy persons as control group. Thyroid function, anti thyroid antibodies, immunological markers, routine laboratory tests, and assessment of RA disease activity were assessed by DAS28 score. Thyroid function in RA patients was analyzed. To compare the difference of thyroid function and anti thyroid antibody between the two groups. The autoantibodies of patients with normal thyroid function and abnormal RA were compared and correlated with DAS28 score of routine laboratory examination. Results there were 30 cases with abnormal thyroid function in RA group, which was higher than that in control group (7 cases). The difference between the two groups was statistically significant (P 0.05). There were 10 cases of hypothyroidism, 6 cases of subclinical hypothyroidism, 9 cases of hypothyroidism syndrome, 3 cases of hyperthyroidism, 2 cases of subclinical hyperthyroidism. The levels of anti-thyroglobulin antibody and anti-thyroid peroxidase antibody were significantly higher than those of control group (P 0.05). Conclusion thyroid dysfunction is easy to occur in RA patients. Thyroid dysfunction is most common in RA patients. There is a correlation between thyroid dysfunction and HGBTc in RA patients.
【作者单位】：重庆市中医院风湿病科;
【基金】：重庆市卫计委医学科研项目(2015MSXM080)
【分类号】：R593.22;R581

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