不同途径短期解除高糖毒性对老年2型糖尿病患者平衡功能的影响

发布时间：2018-05-02 03:54

本文选题：高糖毒性 + 平衡　；参考：《中国现代医学杂志》2017年27期

【摘要】：目的探讨胰岛素不同使用途径短期解除高糖毒性后,对老年2型糖尿病患者平衡功能的影响。方法将符合纳入标准的98例老年2型糖尿病(T2DM)患者作为研究对象,随机分为A组(50例)和B组(48例),A组使用短期持续性皮下胰岛素泵,B组为多次胰岛素皮下注射,通过计时起立-步行测试(TUGT)、单腿站立测试(OLST)来评估患者的动态平衡能力、静态平衡能力,5次坐立测试(FTSST)评估下肢肌力,比较两组治疗前后空腹血糖(FPG)、餐后2 h血糖(2 h PG)、TUGT、OLST(睁)、OLST(闭)、FTSST测试值的变化。结果治疗2周后,同干预前比较,两组FPG、2 h PG、TUGT、OLST(睁)值均有所改善(P0.05),且A组的TUGT、OLST(睁)值优于B组(P0.05),而OLST(闭)、FTSST值前后改善不大,差异无统计学意义(P0.05);TUGT值与年龄、病程、Hb A1c、2 h PG、FTSST值呈正相关(P0.05),与OLST(睁)、OLST(闭)值呈负相关(P0.05);OLST(睁)值与年龄、FPG、TUGT、FTSST值呈负相关(P0.05),与OLST(闭)值呈正相关(P0.05)。结论通过不同胰岛素使用途径特别是胰岛素泵短期解除高糖毒性后,均可改善老年2型糖尿病患者的动态平衡能力及睁眼时静态平衡能力,降低发生跌倒的风险。
[Abstract]:Objective to investigate the effect of insulin on the balance function of elderly patients with type 2 diabetes after the different use of insulin in the short term. Methods 98 elderly patients with type 2 diabetes (T2DM) were selected as subjects and were randomly divided into group A (50 cases) and group B (48 cases). The A group used a short-term continuous subcutaneous insulin pump, and the B group was multiple times. Subcutaneous insulin injection was used to evaluate the patient's dynamic balance ability, static balance ability, 5 standing test (FTSST) assessment of lower limb muscle strength by time standing test (TUGT), single leg standing test (OLST), compared the fasting blood glucose (FPG), postprandial 2 h blood glucose (2 h PG), TUGT, OLST (open), OLST (closed), FTSST test values of the two groups before and after treatment. Results after 2 weeks of treatment, the two groups of FPG, 2 h PG, TUGT and OLST were all improved (P0.05) before the treatment, and the TUGT of the A group was better than the B group (P0.05), and OLST (closed) was not significant before and after the value. The value of closed) was negatively correlated (P0.05); the value of OLST (open) was negatively correlated with age, FPG, TUGT, FTSST value (P0.05) and positively correlated with the value of OLST (closed). Conclusion the dynamic balance ability and static balance ability of the elderly patients with type 2 diabetes can be improved by using different insulin use methods, especially the insulin pump to relieve the high glucose toxicity in the short term. Reduce the risk of falling.

【作者单位】：新乡医学院;河南省人民医院内分泌科;
【基金】：河南省科技厅科技攻关项目(No:132102310466)
【分类号】：R587.1

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