α硫辛酸联合脂微球前列地尔治疗老年早期糖尿病肾脏疾病的疗效观察

发布时间：2018-05-02 07:08

本文选题：α硫辛酸 + 脂微球前列地尔　；参考：《重庆医学》2017年33期

【摘要】：目的探讨α硫辛酸联合脂微球前列地尔治疗老年早期糖尿病肾脏疾病的临床疗效。方法选择2014年1月至2016年1月在郑州大学附属南阳市中心医院接受治疗的164例早期糖尿病肾脏疾病患者,按照随机数字法分为试验组与对照组,每组82例。对照组予以脂微球前列地尔治疗,试验组在对照组的基础上加用α硫辛酸治疗。比较两组患者各项生化指标、临床疗效及皮下淤青、眼底事件发生情况。结果治疗后两组患者尿微量清蛋白(mAIb)、尿视黄醇结合蛋白(U-RBP)、尿N-乙酰β-D氨基葡萄糖苷酶(NAG)水平较治疗前均有明显下降,差异有统计学意义(P0.05)。虽然血清肌酐(Scr)、血尿素氮(Bun)、血胱抑素(CysC)、血β2微球蛋白(β2-MG)有不同程度的下降,但差异无统计学意义(P0.05)。试验组患者治疗有效率为91.46%明显高于对照组的78.05%,差异有统计学意义(P0.05)。试验组患者虽然皮下淤青、眼底事件有上升的趋势,但与对照组比较差异无统计学意义(P0.05)。结论α硫辛酸联合脂微球前列地尔治疗老年早期糖尿病肾脏疾病能够更好地改善肾小球、肾小管功能。
[Abstract]:Objective to investigate the clinical effect of 伪 -lipoic acid combined with lipid microsphere alprostadil in the treatment of early diabetic renal diseases in the elderly. Methods from January 2014 to January 2016, 164 patients with early diabetic renal disease received treatment in Nanyang Central Hospital affiliated to Zhengzhou University. According to the random number method, the patients were divided into experimental group and control group with 82 cases in each group. The control group was treated with alprostadil and the experimental group was treated with 伪 -lipoic acid on the basis of the control group. The biochemical indexes, clinical efficacy and occurrence of subcutaneous bruises and fundus events were compared between the two groups. Results after treatment, the levels of urinary trace albumin (mAIbN), urinary retinol binding protein (U-RBPN) and urinary N-acetyl 尾 -D-glucosaminidase (NAG) in the two groups were significantly lower than those before treatment, and the difference was statistically significant (P 0.05). Although the levels of serum creatinine, bun, cystatin, 尾 2 microglobulin (尾 2 MG) and 尾 2 microglobulin (尾 2 MG) decreased in different degrees, the difference was not statistically significant (P 0.05). The effective rate of treatment was 91.46% in the trial group and 78.05% in the control group. The difference was statistically significant (P 0.05). Although the subcutaneous bruising and fundus events in the trial group were on the rise, there was no significant difference compared with the control group (P 0.05). Conclusion 伪 -lipoic acid combined with lipid microsphere alprostadil can improve glomerular and tubular function better in the elderly with early diabetic renal disease.
【作者单位】：郑州大学附属南阳市中心医院内分泌科;江苏省徐州市中医院内分泌科;
【基金】：国家高技术研究发展计划“863计划”资助项目(2014AA022304)
【分类号】：R587.2;R692.9

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