糖耐量减低合并高甘油三酯血症患者硫氧还原蛋白相互作用蛋白与胰岛功能的相关性研究

发布时间：2018-05-02 15:27

本文选题：糖耐量减低 + 高甘油三酯血症　；参考：《中国糖尿病杂志》2017年12期

【摘要】：目的观察IGT伴或不伴高甘油三酯血症(HTG)患者硫氧还原蛋白相互作用蛋白(TXNIP)与胰岛功能的关系。方法选取IGT患者90例(IGT组),IGT合并HTG患者87例(IGT+HTG组)以及正常对照组(NGT组)90名。检测各组血浆TXNIP水平,静脉葡萄糖耐量试验(IVGTT)评价第一时相胰岛素分泌(FPIR),HOMA-β用于评价基础胰岛功能。结果IGT组血TXNIP水平高于NGT组(P0.05),而IGT+HTG组TXNIP水平进一步升高,与IGT组比较,差异有统计学意义(P0.05)。胰岛β细胞功能指数(HOMA-β)和FPIR在NGT组、IGT组、IGT+HTG组逐渐下降,各组间两两比较,差异有统计学意义(P0.05)。相关分析显示,HOMA-β和FPIR与TXNIP呈负相关(P0.05)。结论 IGT患者血浆TXNIP升高,合并HTG患者升高更明显;基础胰岛功能及早时相胰岛素分泌功能均与血浆TXNIP相关。
[Abstract]:Objective to investigate the relationship between IGT and islet function in patients with or without hypertriglyceridemia. Methods Eighty-seven patients with IGT complicated with HTG were selected from 90 patients with IGT and 90 patients with HTG from normal control group. Plasma TXNIP levels were measured and IVGTT (intravenous glucose tolerance test) was used to evaluate the function of basal islets in the first phase of insulin secretion. Results the serum TXNIP level in IGT group was higher than that in NGT group (P 0.05), but the TXNIP level in IGT HTG group was higher than that in IGT group (P 0.05). The islet 尾 cell function index (HOMA- 尾) and FPIR decreased gradually in NGT group (P 0.05). Correlation analysis showed that HOMA- 尾 and FPIR were negatively correlated with TXNIP (P 0.05). Conclusion Plasma TXNIP is increased in IGT patients, especially in patients with HTG, and insulin secretion is correlated with plasma TXNIP at early stage of basal islet function.
【作者单位】：沧州市中心医院内分泌科;河北省人民医院内分泌科;
【分类号】：R587.1

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