血清性激素结合球蛋白水平对2型糖尿病患者合并代谢综合征的影响研究

发布时间：2018-05-03 02:19

本文选题：性激素结合球蛋白 + 糖尿病　；参考：《中国全科医学》2016年10期

【摘要】：目的探讨血清性激素结合球蛋白(sex hormone-binding globulin,SHBG)水平对2型糖尿病患者合并代谢综合征的影响。方法选取2012年6月—2014年11月到中国医科大学附属第一医院就诊的2型糖尿病患者307例。根据代谢综合征的诊断标准,将纳入患者分为单纯2型糖尿病组(G_0组,n=82)、2型糖尿病合并1项代谢综合征诊断标准组(G_1组,n=46)、2型糖尿病合并2项代谢综合征诊断标准组(G_2组,n=61)、2型糖尿病合并3项代谢综合征诊断标准组(G_3组,n=71)、2型糖尿病合并4项代谢综合征诊断标准组(G_4组,n=47)。收集各组患者的临床资料,探讨血清SHBG水平对2型糖尿病患者合并代谢综合征的影响。结果 5组患者性别、年龄、病程、空腹血糖(FPG)及糖化血红蛋白(Hb A1c)比较,差异无统计学意义(P0.05);5组患者BMI、腰围、收缩压、舒张压、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、血尿酸(UA)、空腹胰岛素及胰岛素抵抗指数(HOMA-IR)比较,差异有统计学意义(P0.05);5组男性患者血清SHBG水平比较,差异有统计学意义(P0.05);5组女性患者血清SHBG水平比较,差异有统计学意义(P0.05);各组不同性别患者血清SHBG水平比较,差异无统计学意义(P0.05)。Pearson相关分析显示,血清SHBG水平与BMI、腰围、FPG、TG、UA、空腹胰岛素、HOMA-IR呈线性负相关(P0.05);与HDL-C呈线性正相关(P0.05)。有序多分类Logistic回归分析显示,血清SHBG水平对2型糖尿病患者合并代谢综合征的影响有统计学意义(P0.05)。结论血清SHBG水平是2型糖尿病患者合并代谢综合征的影响因素,较低血清SHBG水平患者的患病风险较大。
[Abstract]:Objective to investigate the effect of serum sex hormone-binding globulin (SHBG) on type 2 diabetic patients with metabolic syndrome. Methods 307 cases of type 2 diabetic patients were selected from June 2012 to November 2014 to the First Affiliated Hospital of China Medical University. According to the diagnostic criteria of metabolic syndrome, the patients will be included in the patient. The patients were divided into simple type 2 diabetes group (group G_0, n=82), type 2 diabetes combined with 1 metabolic syndrome diagnostic standard group (group G_1, n=46), type 2 diabetes combined with 2 metabolic syndrome diagnostic standard group (G_2 group, n=61), type 2 diabetes combined with 3 metabolic syndrome diagnostic standard group (G_3 group, n=71), type 2 diabetes mellitus combined with 4 metabolic syndrome diagnostic standard group (group G_4, n=47). The clinical data of each group were collected to explore the effect of serum SHBG level on type 2 diabetic patients with metabolic syndrome. Results there was no significant difference in sex, age, course of disease, fasting blood glucose (FPG) and glycated hemoglobin (Hb A1c) in the 5 groups (P0.05); the 5 groups of patients were BMI, waistline, systolic pressure, diastolic blood pressure, and three acyl glycerol (TG), the difference of high density lipoprotein cholesterol (HDL-C), blood uric acid (UA), fasting insulin and insulin resistance index (HOMA-IR) was statistically significant (P0.05). The difference of serum SHBG level in 5 groups of male patients was statistically significant (P0.05); the difference of serum SHBG level in the 5 groups of female patients was statistically significant (P0.05); the differences in each group were different. The difference in serum SHBG level was not statistically significant (P0.05).Pearson correlation analysis showed that serum SHBG levels were linear negative correlation with BMI, waist circumference, FPG, TG, UA, fasting insulin, and HOMA-IR (P0.05), and linear positive correlation with HDL-C (P0.05). The effect of metabolic syndrome is statistically significant (P0.05). Conclusion serum SHBG level is an influential factor in type 2 diabetic patients with metabolic syndrome, and the risk of patients with lower serum SHBG level is greater.

【作者单位】：中国医科大学附属第四医院内分泌科;
【基金】：辽宁省科学技术厅项目(L2011225020) 沈阳市科学技术项目(F11-264-1-50)
【分类号】：R587.1;R589

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