山西地区成人碘营养状况与甲状腺疾病相关性的研究

发布时间：2018-05-03 04:36

本文选题：碘营养 + 甲状腺功能亢进症　；参考：《山西医科大学》2017年硕士论文

【摘要】：目的:了解山西地区成年人群目前的碘营养状况,以及甲状腺疾病的患病情况,探讨碘摄入与甲状腺疾病之间的相关性。方法:本研究采用随机抽样的方法,按照入选标准和排除标准,共选取参与2015年山西地区甲状腺疾病调查的2479名健康体检者(其中城市人群1322人、农村人群1157人),全部受试者均进行问卷调查、体检、采集血标本测定甲状腺功能、留取晨尿用于尿碘测定、甲状腺超声检查。调查对象的基本信息及化验结果全部录入数据库,整理、分析实验数据。结果:1.山西地区成人MUI为214.7ug/L,男性MUI明显高于女性(220.5ug/L vs205.6ug/L),差异具有统计学意义(P=0.037)。青年组MUI高于中年组(224.7 ug/L vs 203.6 ug/L),中年组高于老年组(203.6 ug/L vs 185.5 ug/L),三组人群的MUI经秩和检验,P0.001,差异具有统计学意义。城市成人MUI(186.2ug/L)明显低于农村成人MUI(245.7ug/L),差异具有统计学意义(P0.001)。2.甲状腺疾病患病率分别为:甲减(0.6%)、亚临床甲减(15.7%)、甲亢(0.5%)、亚临床甲亢(0.7%)及甲状腺结节(9.9%)。城市人群甲状腺结节患病率(12.1%)明显高于农村的甲状腺结节患病率(7.7%),差异具有统计学意义。城市人群甲减、亚临床甲减、甲亢、亚临床甲亢患病率,与农村相比,差异无统计学意义。3.不同碘营养组TPOAb阳性率及TPOAb和TGAb均阳性率之间差异无统计学意义,而TSH水平及TGAb阳性率之间差异具有统计学意义。不同碘营养组甲减、亚甲减、甲亢、亚甲亢及甲状腺结节的患病率之间,差异无统计学意义。结论:1.山西地区成人碘水平基本处于碘超足量的状态。2.不同碘营养组之间,TPOAb阳性率差异无统计学意义,TSH水平及TGAb阳性率差异具有统计学差异,碘超足量水平的TSH水平及TGAb的阳性率最低。不同碘水平组间甲状腺疾病的患病率没有统计学差异。
[Abstract]:Objective: to investigate the iodine nutritional status of adult population and the prevalence of thyroid disease in Shanxi province and to explore the correlation between iodine intake and thyroid disease. Methods: according to the inclusion criteria and exclusion criteria, a total of 2479 healthy people (including 1322 urban residents) who participated in the investigation of thyroid diseases in Shanxi in 2015 were selected by random sampling. 1157 people from rural areas were investigated by questionnaire, physical examination, blood samples were collected to determine thyroid function, morning urine was reserved for urine iodine determination, and thyroid ultrasound examination was performed. The basic information and test results of the subjects were entered into the database, collated and analyzed the experimental data. The result is 1: 1. The MUI of adults in Shanxi area was 214.7ugP / L, and the MUI of males was significantly higher than that of females (220.5ugP / L vs 205.6ugP / L), and the difference was statistically significant (0.037g / L). The MUI of the young group was higher than that of the middle-aged group (224.7 ug/L vs 203.6 ugP / L), and that of the middle-aged group was higher than that of the elderly group (203.6 ug/L vs 185.5 ugr / L). The MUI of the three groups was significantly higher than that of the middle age group by rank sum test (P 0.001). Urban adults (186.2ugr / L) were significantly lower than rural adults (245.7ugP / L). The difference was statistically significant (P 0.001g / L). The prevalence rates of thyroid diseases were as follows: hypothyroidism 0.6, subclinical hypothyroidism 15.7m, hyperthyroidism 0.5, subclinical hyperthyroidism 0.7) and thyroid nodule 0.9. The prevalence of thyroid nodules in urban population was significantly higher than that in rural areas (P < 0.01). The prevalence of hypothyroidism, subclinical hypothyroidism, hyperthyroidism and subclinical hyperthyroidism in urban population was not significantly different from that in rural areas. There was no significant difference in TPOAb positive rate, TPOAb and TGAb positive rate between different iodine nutrition groups, but there was significant difference between TSH level and TGAb positive rate. There was no significant difference in the prevalence of hypothyroidism, hypothyroidism, hyperthyroidism and thyroid nodule in different iodine nutrition groups. Conclusion 1. The adult iodine level in Shanxi area is basically in the state of iodine excess. There was no significant difference in the positive rate of TPOAb and TGAb between different iodine nutrition groups. The level of TSH and the positive rate of TGAb were the lowest at the level of iodine excess. There was no significant difference in the prevalence of thyroid disease among groups with different iodine levels.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R581

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