石河子社区2型糖尿病患者药物治疗3年随访研究

发布时间：2018-05-03 07:31

本文选题：型糖尿病 + 降糖方案　；参考：《实用医学杂志》2017年18期

【摘要】：目的研究近3年间石河子社区管理2型糖尿病(T2DM)患者降糖方案构成比和临床结局变化情况。方法采用整群抽样的方法于2012年11月从石河子的13个社区随机抽取符合标准的T2DM患者300例,进行为期3年的随访观察,收集一般人口学信息、治疗方案、临床结局等资料。结果与2012年比较,2015年口服药物组患者比例从63.5%降低到51.0%,胰岛素治疗组从30.8%增加到41.8%,其中单药治疗组的比例明显下降(χ~2=8.77,P0.05),胰岛素联合口服药物组的比例明显上升(χ~2=-10.27,P0.01),用药不良反应发生率从16.8%增高至24.5%;2015年血糖指标及达标率较2012年无明显变化,2015年血糖达标率按(1)标准计算为41.2%,较2012年减少了4.0%,按(2)标准计算为52.9%,较2012年增加了1.4%;2015年糖尿病合并症和并发症较2012年明显增加。结论 (1)石河子社区T2DM患者治疗以口服药物治疗为主,胰岛素的使用率有所上升;(2)石河子社区在T2DM患者血糖达标、用药安全性、延缓其并发症及合并症进展等方面有待提高。
[Abstract]:Objective to study the changes of the composition ratio of hypoglycemic regimen and clinical outcome in patients with type 2 diabetes mellitus (T2DM) managed in Shihezi community in recent three years. Methods three hundred T2DM patients were randomly selected from 13 communities in Shihezi by cluster sampling in November, 2012. The data of general demographic information, treatment scheme and clinical outcome were collected for a period of 3 years. Results compared with 2012, the proportion of patients in oral drug group decreased from 63.5% to 51.0% in 2015, and that in insulin treatment group increased from 30.8% to 41.8%, in which the proportion of single drug group decreased significantly (蠂 ~ (2 +) 8.77) P 0.05, and the proportion of insulin combined oral drug group increased significantly (蠂 ~ (2) -10.27 P _ (0.01), P < 0.05). The incidence of adverse drug reactions increased from 16.8% to 24.5%, and there was no significant change in the blood glucose index and the rate of reaching the standard in 2015 compared with 2012. The 2015 blood glucose reached standard rate was 41.2%, which was 4.0% lower than that in 2012, and 52.9% higher than that in 2012, which was 1.4 cents higher than that in 2012. Urinary complications and complications increased significantly compared with 2012. Conclusion 1) Oral drug therapy is the main treatment for T2DM patients in Shihezi community, and the utilization rate of insulin has increased. 2) in Shihezi community, blood glucose standard, drug safety, complications and complications in Shihezi community need to be improved.
【作者单位】：石河子大学医学院第一附属医院内分泌科;
【基金】：兵团科技攻关与成果转化项目(编号:2015AD006)
【分类号】：R587.1

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