益肾化湿颗粒联合吗替麦考酚酯治疗狼疮性肾炎效果观察

发布时间：2018-05-06 03:14

本文选题：益肾化湿颗粒 + 吗替麦考酚酯　；参考：《山东医药》2017年18期

【摘要】：目的观察益肾化湿颗粒联合吗替麦考酚酯(MMF)治疗狼疮性肾炎(LN)的临床疗效。方法将52例LN患者随机分成观察组和对照组各26例,均予甲基泼尼松龙冲击治疗3 d后改为泼尼松片口服,观察组口服益肾化湿颗粒与MMF分散片,对照组单纯口服MMF分散片。每2个月为1个疗程,治疗3个疗程。分别于治疗第2、4、6个月,检测24 h尿蛋白定量、血清白蛋白、血肌酐评价临床疗效,取静脉血检测抗双链DNA(ds-DNA)抗体和补体C3,记录不良反应。结果在治疗第2、4、6个月,观察组总有效率分别为76.9%、84.6%、92.3%,对照组分别为30.8%、46.2%、65.4%,两组总有效率比较P均0.05;治疗第4、6个月,观察组抗ds-DNA抗体转阴和补体C3恢复正常比例高于对照组(P均0.05)。观察组不良反应发生率为11.5%,低于对照组的42.3%(P0.05)。结论益肾化湿颗粒联合MMF治疗LN可提高临床疗效,抑制狼疮活动,且不良反应少。
[Abstract]:Objective to observe the clinical effect of Yishen Huashi granule combined with Mutimefen Ester (MMF) in the treatment of lupus nephritis (LN). Methods 52 patients with LN were randomly divided into two groups: the observation group (n = 26) and the control group (n = 26). All patients were treated with methylprednisolone for 3 days and then treated with prednisone tablets. The observation group was treated with Yishenhuashi granules and MMF dispersible tablets, and the control group was treated with MMF dispersible tablets only. Every 2 months as a course of treatment, 3 courses of treatment. 24 h urinary protein quantification, serum albumin and serum creatinine were measured at the 2nd and 6th month after treatment to evaluate the clinical efficacy. The venous blood was taken to detect the antibody against double strand DNA ds-DNA and complement C3, and the adverse reactions were recorded. Results in the 2nd month and 6th month of treatment, the total effective rate of the observation group was 76.9 / 84.6 and the control group was 30.8 / 46.2and 65.4respectively, the total effective rate of the two groups was both 0.05, and at the 4th and 6th month of treatment, the ratio of anti-negative antibody and complement C _ 3 in the observation group was higher than that in the control group (P < 0.05). The incidence of adverse reactions in the observation group was 11.5, which was lower than that in the control group (42.3%, P 0.05). Conclusion Yishen Huashi granule combined with MMF can improve the clinical efficacy, inhibit lupus activity, and have less adverse reactions.
【作者单位】：南方医科大学;中国人民解放军第181医院;
【基金】：广西重点实验室建设计划项目(15-140-10)
【分类号】：R593.242

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