培哚普利对维甲酸致骨质疏松大鼠骨组织结构的影响

发布时间：2018-05-06 07:23

本文选题：培哚普利 + 骨质疏松　；参考：《中国老年学杂志》2017年24期

【摘要】：目的探讨血管紧张素酶转化抑制剂(ACEI)培哚普利对骨质疏松大鼠骨组织的作用。方法将大鼠随机分为A、B、C、D、E五组,A、B、C、D 4组用80 mg·kg~(-1)·d~(-1)的维甲酸(RA)造模,E组为对照组,造模成功后A、B、C 3组再用8、4、2 mg·kg~(-1)·d~(-1)培哚普利给药,D、E两组灌予等量蒸馏水。实验过程中记录体重变化,2个月后行病理切片苏木精-伊红(HE)染色观察骨组织显微结构。结果培哚普利干预后骨组织与干预前比较:A组骨小梁中断较少,连接尚可,间距较前减小;B组骨小梁数量较前增多,仍有稀疏、变细,仍可见中断,间距无明显变化;C、D组表现类似,可见骨小梁疏松、中断,小梁间的网孔增大,小梁间连接减少;E组较前无明显变化;A、B、C 3组以A组作用较明显。结论培哚普利可促进骨形成,有效地拮抗RA造模大鼠骨质疏松的进展,且促进骨形成的作用呈剂量依赖性。
[Abstract]:Objective to investigate the effect of angiotensin converting inhibitor (ACEI) perindopril on bone tissue of osteoporosis rats. Methods the rats were randomly divided into five groups: group D _ (4) treated with 80 mg 路kg ~ (-1) retinoic acid) as control group, and group C _ (3) was given 82mg / kg (kg ~ (-1) D ~ (1) perindopril for the same amount of distilled water. The changes of body weight were recorded during the experiment. After 2 months, the microstructure of bone tissue was observed by hematoxylin-eosin (HEH) staining. Results the bone tissue after perindopril intervention was less broken than that before the intervention, and the bone trabeculae in group A were well connected. The number of trabeculae in group B was more than that in group B, and the bone trabeculae in group B were still sparse, thinned and interrupted. There was no significant change in the distance between the two groups. The results showed that the trabeculae were loose and interrupted, the meshes between trabeculae increased, and the intertrabecular connections decreased in group E. The effect of group A was more obvious than that of group C 3. Conclusion Perindopril can promote bone formation and effectively antagonize the progression of osteoporosis in RA model rats, and the effect of perindopril on bone formation is dose-dependent.
【作者单位】：中山大学附属第五医院老年病科;珠海市人民医院干部保健老年病科;
【分类号】：R580

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