2型糖尿病血清分泌型卷曲相关蛋白4水平及其与胰岛β细胞功能的关系探讨

发布时间：2018-05-07 03:39

本文选题：分泌型卷曲相关蛋白4 + 第一时相胰岛素分泌　；参考：《重庆医科大学》2015年硕士论文

【摘要】：目的：探讨不同糖耐量状态下分泌型卷曲相关蛋白4(SFRP4)与胰岛β细胞第一时相分泌功能的关系。方法：首次确诊为2型糖尿病患者56例(T2DM组)；糖耐量减低52例(IGT组)；正常对照者42例(NGT组)。行静脉葡萄糖耐量试验,ELISA法测定血清分泌型卷曲相关蛋白4(SFRP4)及IL-1β水平。计算急性胰岛素分泌反应(AIR)、第一时相(0-10min)胰岛素分泌(AUC)、葡萄糖处置指数(GDI)、稳态模型评估胰岛β细胞功能(HOMA-p)及胰岛素抵抗(HOMA-IR)。探讨SFRP4与AIR、 AUC、GDI、HOMA-IR、HOMA-β的关系。结果：(1)T2DM组和IGT组血清SFRP4水平显著高于NGT组(P0.01)；T2DM组和IGT组AIR、AUC、GDI显著低于NGT组(P0.01)且在T2DM组最低；(2)SFRP4与HOMA-β、AIR、AUC、 GDI呈显著负相关(P0.01),与FPG.2hPG、HbA1c、IL-1β、hs-CRP呈正相关(P0.01)。(3)多元逐步回归分析显示,AUC、HOMA-IR、 IL-1β是SFRP4的独立影响因素。结论：血清SFRP4水平与糖代谢状态密切相关,且与胰岛β细胞第一时相分泌功能及慢性低度炎症反应有关,SFRP4可能参与2型糖尿病的发生发展。
[Abstract]:Aim: to investigate the relationship between secretory crimp associated protein 4 (SFRP4) and the first phase secretion of islet 尾 cells under different glucose tolerance. Methods: 56 patients with type 2 diabetes were diagnosed as T2DM for the first time, 52 patients with impaired glucose tolerance (IGT) and 42 normal controls with NGT. The levels of serum secretory crimp associated protein 4 (SFRP4) and IL-1 尾 were measured by intravenous glucose tolerance test (IVGTT) and Elisa. The acute insulin secretion response (AIRN) and glucose disposal index (GDI) were calculated in the first phase from 0 to 10 min. The homeostasis model was used to evaluate the function of islet 尾 cells and insulin resistance. To study the relationship between SFRP4 and AIR, AUCGDIH HOMA-IRN HOMA- 尾. Results the level of serum SFRP4 in T2DM group and IGT group was significantly higher than that in NGT group P0.01T2DM group and IGT group (P 0.01). In T2DM group, there was a significant negative correlation between Homa 2SFRP4 and HOMA- 尾 AIRAUC, GDI, and a positive correlation between GDI and FPG.2hPGA1cHbA1C 尾 -hs-CRP. The stepwise regression analysis showed that AUCHOMA-IRR, IL-1 尾 was an independent influencing factor of SFRP4. Conclusion: the level of serum SFRP4 is closely related to the state of glucose metabolism, and may be involved in the development of type 2 diabetes mellitus, and may be related to the first phase secretion of islet 尾 cells and chronic low-grade inflammation.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R587.1

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