睡眠时间与糖代谢的相关性研究

发布时间：2018-05-07 17:42

本文选题：睡眠时间 + 糖调节受损　；参考：《兰州大学》2017年硕士论文

【摘要】：目的分析人群睡眠时间状况和糖代谢情况,并探讨睡眠时间与糖代谢的相关性。方法利用“Reaction”研究甘肃地区资料,抽取兰州市社区40~75岁符合条件的居民共8526例进行研究。提取性别、年龄、入睡时间、起床时间、睡眠状况、打鼾情况、独居情况、职业状态,测量身高、体重、腰围(WC)、臀围(HC)、收缩压(SBP)、舒张压(DBP),检测空腹血糖(FBG)、负荷后2小时血糖(2hPG)、糖化血红蛋白(HbA1c)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、总胆固醇(TC)等。按夜间睡眠时间5小时(h)、~6h、~7h、~8h、~9h、9h将研究人群共分为6组。统计并分析该人群的睡眠时间状况,并探讨不同睡眠时间分组与正常糖耐量(NGT)、糖调节受损(IGR)、糖尿病(DM)之间的相关性。结果(1)8526例研究对象中,男性2446例(28.7%)、女性6080例(71.3%)。平均年龄(57.5±8.4)岁,平均体质量指数(BMI)为(24.1±3.2)kg/m2。平均睡眠时间为(7.62±1.16)h,男女睡眠时间无显著性差异(P0.05)。研究人群的IGR、DM患病率分别为28.1%、23.9%,男性DM的患病率高于女性(31.5%vs 20.9%,P0.05)。(2)睡眠时间5h组、~6h组、~7h组、~8h组、~9h组、9h组中的人群平均睡眠时间分别为(3.54±0.92)h、(5.75±0.40)h、(6.85±0.28)h、(7.79±0.32)h、(8.67±0.35)h、(9.89±0.88)h。各组分别占总人群比例分别为1.3%、19.1%、23.6%、39.6%、21.1%、5.2%。(3)单因素方差分析表明,不同睡眠时间下FBG、HbA1c、HDL、LDL、TC均有显著性(P均0.05)。将睡眠时间~8h设为参照组,睡眠时间5h的FBG、HbA1C水平较参照组高(P均0.05)。HDL-C、TC均在睡眠时间~9h偏低和睡眠时间~6h偏高(P均0.05)。与参照组相比,睡眠时间~9h时BMI水平偏低(P0.05)。(4)在研究对象中,NGT、IGR、DM者所占百分比分别是47.9%、28.1%、23.9%,52%研究对象患有糖代谢异常。总的来说,糖代谢异常人群的年龄偏大,血糖水平(FBG、2hPG、Hb A1c)、血脂水平(LDL、TG、TC)、BMI、WC、SBP和DBP均偏高(P均0.05)。(5)睡眠时间5h组的DM的患病率较其它睡眠时间组偏高(P0.05)。不同睡眠时间分组下,IGR患病率无显著性差异(P均0.05)。不同睡眠时间分组下男女IGR、DM患病率无显著性差异(P0.05)。(6)Logistic回归分析显示:将睡眠时间~8h设为参照组,DM、IGR患病率设为因变量,未调整混杂因素时,睡眠时间5h可增加DM、男性IGR的患病风险。在上述基础上,调整年龄、性别、WC、HDL-C、LDL-C、TG、TC、睡眠情况、打鼾史、文化程度、职业状态、独居情况、体力活动、高血压、血脂异常、糖尿病家族史、饮酒史及吸烟史因素后,睡眠时间5h仍可以增加DM、男性IGR的患病风险。进一步调整BMI因素,上述相关性仍存在统计学差异。结论睡眠时间5h与男性IGR的患病风险呈正相关,睡眠时间5h是男性IGR的独立危险因素。睡眠时间5h与DM的患病风险呈正相关,睡眠时间5h是DM的独立危险因素。
[Abstract]:Objective to investigate the relationship between sleep time and glucose metabolism. Methods A total of 8526 eligible residents aged 4075 years in the community of Lanzhou City were studied by "Reaction". Sex, age, time to fall asleep, time to get up, sleep status, snoring, solitude, professional status, measurement of height, weight, WCU, HCG, SBP, DBP, FBGG, 2hPGN, HbA1cn, HDL-CU, LDL-CGN, TGN, TGN, TGN, TGN, TBGG, HbA1cU, HDL-CU, LDL-CU, TGN, TGN, TGG, et al in waist circumference, hip circumference, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood glucose (FBGG), 2hPGN after loading, HbA1cn, HDL-CU, LDL-CU, TGN, TCC, et al. The study group was divided into 6 groups according to the sleep time of 5 hours at night, 6 hours, 7 hours, 8 hours, 9 hours and 9 hours. The sleep time status of this population was statistically analyzed and the correlation between different sleep time groups and normal glucose tolerance (NGT), impaired glucose regulation (IGR) and diabetes mellitus (DM) was discussed. Results among 8526 subjects, 2446 cases were male and 6080 cases were female. The mean age was 57.5 卤8.4 years, and the mean body mass index (BMI) was 24.1 卤3.2kg 路kg / m ~ (2). The average sleep time was 7.62 卤1.16h. there was no significant difference in sleep time between male and female (P 0.05). The prevalence rate of IGRN DM in the study population was 28.1and 23.9.The prevalence rate of DM in males was higher than that in females (31.5 vs 20.9). The average sleep time was 8.67 卤0.35hmh in 5h group, 7h group in 7h group and 7h group in 8h group. The average sleep time in 9h group was 3.54 卤0.92hU (5.75 卤0.40hmh) 7.79 卤0.32hmh (8.67 卤0.35hmh). The ratio of each group to the total population was 1.3and 19.1and 23.6cm, respectively. The single factor analysis of variance showed that there were significant differences in LDLTC between HbA1C and HDLLDLTc under different sleep time (P < 0.05). The HbA1C level of the 5h sleep time group was higher than that of the control group (P < 0.05). HDL-CU TC was lower than that of the control group during sleep time of 9 hours and the sleep time of 6 hours was higher than that of the control group (P < 0.05). Compared with the control group, the percentage of patients with NGT IGR DM was 47.9% and 28.1g / 23.9% of the subjects had abnormal glucose metabolism. In general, the age of people with abnormal glucose metabolism was higher than that of other sleep time groups. The prevalence of DM in patients with abnormal glucose level was higher than that in other sleep time groups (P < 0.05), and the blood glucose level was higher than that in other sleep time groups (P < 0.05). There was no significant difference in the prevalence of IGR among different sleep time groups (P < 0.05). There was no significant difference in the prevalence rate of IGR between men and women under different sleep time groups. Logistic regression analysis showed that the prevalence rate of IGR in the control group was set as dependent variable when the sleep time was 8 hours, and the risk of IGR was increased when the sleep time was not adjusted for 5 hours. On the above basis, after adjusting for age, sex, HDL-C, LDL-C, sleep, history of snoring, education, occupational status, living alone, physical activity, hypertension, dyslipidemia, family history of diabetes, history of drinking and smoking, Sleeping for 5 hours still increased the risk of IGR in men. Further adjustment of BMI factors, the above correlation still exist statistical difference. Conclusion 5 h sleep time is positively correlated with the risk of IGR in men, and 5 h sleep time is an independent risk factor for male IGR. 5 h sleep time was positively correlated with the risk of DM, and 5 h sleep time was an independent risk factor for DM.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R587.1

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