类胰蛋白酶在过敏性疾病诊断中的研究进展

发布时间：2018-05-08 10:29

本文选题：类胰蛋白酶 + 肥大细胞　；参考：《中成药》2016年06期

【摘要】：类胰蛋白酶属于肥大细胞和嗜碱性粒细胞的特异性活性物质,当激活时以肥大细胞脱颗粒形式与其它介质一起释放,具有促进气道的修复、调节气道平滑肌细胞的张力和反应性、刺激肥大细胞的活化等作用,与支气管哮喘、慢性荨麻疹、过敏性休克、全身过敏反应等病情相关,在中药注射剂过敏性疾病的鉴别诊断中起重要作用。本文主要从类胰蛋白酶的分子生物学基础、功能、生物稳定性、检测方法及其对过敏性疾病的诊断等方面进行了综述,以期为类胰蛋白酶作为生物标志物在诊断过敏性疾病中的应用提供参考。
[Abstract]:Trypsin is a specific active substance of mast cells and basophilic granulocytes. When activated, trypsin is released in the form of mast cell degranulation with other mediums, which promotes airway repair. Regulating the tension and responsiveness of airway smooth muscle cells and stimulating the activation of mast cells are related to asthma, chronic urticaria, anaphylactic shock, systemic allergic reaction, etc. It plays an important role in the differential diagnosis of allergic diseases of traditional Chinese medicine injection. In this paper, the molecular biological basis, function, biological stability, detection methods and diagnosis of allergic diseases of trypsin are reviewed. In order to provide reference for the application of trypsin as a biomarker in the diagnosis of allergic diseases.
【作者单位】：上海中医药大学药物安全评价研究中心;
【基金】：国家“十二五”科技重大专项(2011ZX09301-009)
【分类号】：R593.1

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